1 2 4 Oxadiazoles
Mostrando 1-11 de 11 artigos, teses e dissertações.
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1. INOVAÇÃO E PROPRIEDADE INTELECTUAL DOS 1,2,4-OXADIAZÓIS: UMA PROSPECÇÃO TECNOLÓGICA FUNDAMENTADA EM BASE DE DADOS DE PATENTES E PERIÓDICOS
1,2,4-Oxadiazoles are heterocyclic compounds that have a remarkable range of applications. This overview focused on investigating the potential and scientific and technological evolution of these compounds through an analysis of patent databases and scientific papers. Prospecting technology using patent databases is an important tool for mapping technologies
Quím. Nova. Publicado em: 2018-06
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2. 1,2,4- and 1,3,4-Oxadiazoles as Scaffolds in the Development of Antiparasitic Agents
In this review, we present the potential use of the heterocyclic oxadiazole rings in the design and synthesis of new drugs to treat parasitic infections. We intend to compare herein all the four isomeric forms of oxadiazole rings as well as discuss the differences and similarities between them. In addition, we discuss aspects on their reactivity that justify
J. Braz. Chem. Soc.. Publicado em: 2018-03
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3. Strategies for the Efficient Synthesis of Biheterocyclic 5-[2-(Trifluoromethylheteroaryl)-ethyl]-1,3,4-oxadiazoles from Levulinic Acid
The synthesis of 5-[2-(trifluoromethylheteroaryl)-ethyl]-1,3,4-oxadiazoles derived from levulinic acid is reported. Cyclocondensations [4 + 1] between four different 5-[2-(trifluoromethylheteroaryl)propionylhydrazides derived from methyl 7,7,7-trifluoro-4-methoxy-6-oxo-4-heptenoate obtained from levulinic acid, and electrophilic orthoesters RC(OR1)3 (where R
J. Braz. Chem. Soc.. Publicado em: 2017-11
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4. PREPARAÇÃO DE 1,2,4-OXADIAZOL: SEQUÊNCIA DIDÁTICA APLICADA EM DISCIPLINA DE SÍNTESE ORGÂNICA NA GRADUAÇÃO
1,2,4-oxadiazoles are used in a wide range of applications, including medicinal chemistry and chemistry of materials. However, this kind of oxadiazoles is not usually prepared in an undergraduate organic teaching laboratory. This work describes a didactic sequence for the preparation of 1,2,4-oxadiazols, mediated by microwave irradiation, employing home-use
Quím. Nova. Publicado em: 2016-09
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5. Toxicological Evaluation of Anti-Scrapie Trimethoxychalcones and Oxadiazoles
Uma forma alterada da proteína prion celular, a PrPSc ou PrPRes, está envolvida na ocorrência das encefalopatias espongiformes transmissíveis. Nós sintetizamos e caracterizamos previamente compostos aromáticos que inibem o acúmulo da proteína prion resistente a proteases (PrPRes) em células infectadas com prion scrapie. Estes compostos pertencem a d
An. Acad. Bras. Ciênc.. Publicado em: 04/08/2015
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6. An easy synthesis of 3,5-disubstituted 1,2,4-oxadiazoles from carboxylic acids and arylamidoximes mediated by ethyl chloroformate
Uma síntese limpa, fácil e eficiente de vários 1,2,4-oxadiazóis 3,5-dissubstituídos partindo de um anidrido misto (gerado a partir de um ácido carboxílico e cloroformiato de etila) e amidoxima é descrita.
Journal of the Brazilian Chemical Society. Publicado em: 2009
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7. Silica-supported dichlorophosphate: a recoverable cyclodehydrant for the eco-friendly synthesis of 2,5-disubstituted 1,3,4-oxadiazoles under solvent-free and microwave irradiation conditions
Uma série de compostos simétricos e assimétricos de 2,5-dissubstituídos 1,3,4-oxadiazol foram sintetizados eficientemente a partir do ciclodesidratação das diacilhidrazinas, usando a sílica suportada com o diclorofosfato, como recuperador do ciclodesidratação sem solvente e sob irradiação por microondas. Este processo tem vantagens de ser não cor
Journal of the Brazilian Chemical Society. Publicado em: 2008
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8. SÃNTESE DE 1,2,4-OXADIAZÃIS ENANTIOMERICAMENTE ENRIQUECIDOS E DE NOVOS GLICOCONJUGADOS POTENCIALMENTE ATIVOS
Neo-glicoconjugados constituem uma classe de compostos em que os carboidratos estÃo conjugados a outras molÃculas de interesse biolÃgico. Os 1,2,4-oxadiazÃis sÃo heterociclos bastante conhecidos em quÃmica medicinal, apresentando vÃrias atividades farmacolÃgicas e tendo sido considerados bioisÃsteros de Ãsteres e amidas. Este trabalho descreve a s�
Publicado em: 2008
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9. 1,2,4-oxadiazÃis: sÃntese, desenvolvimento de novas metodologias sintÃticas e avaliaÃÃo da atividade antiinflamatÃria
This work describes the obtainment of many novel 3,5-disubstituted 1,2,4-oxadiazoles. First, the synthesis of ten previously unknown 3-aryl-5-tridecyl- and 3-aryl-5-heptadecyl-1,2,4- oxadiazoles 40a-g, 40h-j, starting from arylamidoximes 12a-g and tetradecanoic as well as heptadecanoic acids 38a and 38b is reported. Second, seven new 3-aryl-5-(cis-heptadec-1
Publicado em: 2007
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10. Synthesis of new 1,2,4-oxadiazoles carrying (1'S,2'S)-t-butyloxycarbonyl-1-amino-2- methyl-1-butyl and (1'S)-t-butyloxycarbonyl-1'-amino-1'-ethyl groups at C-5
Uma síntese fácil e eficiente de 3-aril-5[(1S)-t-butiloxicarbonil-1-amino-( 2S)-metil-1-butil)]-1,2,4-oxadiazóis 4a-f e 3-fenil-5-[(1S)-t-butiloxicarbonil-1-amino-1-etil]-1,2,4-oxadiazol 6 partindo de arilamidoximas, N-t-Boc-L-isoleucina e N-t-Boc-L-alanina é descrita. As estruturasedos intermediários e compostos finais foram determinadas a partir dos d
Journal of the Brazilian Chemical Society. Publicado em: 2004-08
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11. Influence of chemical structure on the mesomorphic behaviour of 3,5-disubstituted 1,2,4-oxadiazoles
The correlation between chemical structure and mesomorphic properties is one of the most important problems in liquid crystals science. 3,5-Disubstituted 1,2,4-oxadiazoles are very convenient model-compounds for studying the dependence of the LC properties on the molecular design. The transition temperatures and dielectric properties of 1,2,4-oxadiazoles dep
Brazilian Journal of Physics. Publicado em: 2002-06