2 Antigenotoxic
Mostrando 1-12 de 18 artigos, teses e dissertações.
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1. Assessment of the toxicogenic effects and cell death potential of the ester (Z)-methyl 4-((1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)amino)-4-oxobut-2-anoate in combination with cisplatin, cyclophosphamide and doxorubicin
Abstract Despite rapid advances in both the early detection and treatment of cancer, the mortality from this disease remains high, which justifies the development of new products that are more selective and effective and have fewer side effects. Accordingly, a novel ester was synthesized that contains two pharmacophores with important biological activities:
Genet. Mol. Biol.. Publicado em: 27/06/2019
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2. Assessment of the antiproliferative and antigenotoxic activity and phytochemical screening of aqueous extracts of Sambucus australis Cham. & Schltdl. (ADOXACEAE)
ABSTRACT The purpose of this study was to evaluate the antiproliferative and antigenotoxic activity of Sambucus australis Cham. & Schltdl. aqueous extracts on the cell cycle of Allium cepa L. as well as determine the phenolic compounds in such extracts. S. australis inflorescences and leaves of two accessions were used for aqueous extract preparation at conc
An. Acad. Bras. Ciênc.. Publicado em: 31/08/2017
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3. Isolation and characterization of flavanols from Anthocephalus cadamba and evaluation of their antioxidant, antigenotoxic, cytotoxic and COX-2 inhibitory activities
ABSTRACT In search of lead molecules for use in disease prevention and as food additive from natural sources, two flavanols were isolated from leaves of Anthocephalus cadamba (Roxb.) Miq., Rubiaceae. Their structures were established as 6-hydroxycoumarin-(4"→8)-(-)-epicatechin and 6-hydroxycoumarin-(4"→8)-(-)-epicatechin-(4→6‴)-(-)-epicatechin on the
Rev. bras. farmacogn.. Publicado em: 2016-08
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4. In vivo evaluation of the antimutagenic and antigenotoxic effects of β-glucan extracted from Saccharomyces cerevisiae in acute treatment with multiple doses
Ample evidence suggests that cancer is triggered by mutagenic damage and diets or supplements capable of reducing such incidences can be related to the prevention of neoplasy development or to an improvement in life quality of patients who undergo chemotherapy. This research aimed to evaluate the antimutagenic and antigenotoxic activity of β-glucan. We set
Genet. Mol. Biol.. Publicado em: 19/07/2013
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5. Antigenotoxic activity of diet compounds and their influence in the expression of genes involved in response to oxidative stress / Atividade antigenotóxica de compostos da dieta e sua influência na expressão de genes de resposta ao estresse oxidativo
Os pigmentos naturais, além de fornecerem cor e beleza aos diferentes organismos, desempenham importantes funções e ações biológicas, como as funções vitais de fotossíntese, respiração celular e a ação antioxidante. Assim, o presente estudo investigou os potenciais citotóxicos, genotóxicos e protetores dos pigmentos naturais clorofila b (CLb)
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 30/03/2012
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6. Atividade antioxidante de extratos e compostos isolados de Eugenia umbelliflora e Rapanea ferrugínea / ANTIOXIDANT ACTIVITY OF ISOLATED COMPOUNDS AND EXTRACTS OF Eugenia umbelliflora and Rapanea ferruginea
Eugenia umbeliflora is popularly known as baguaçu, guapê or guaramirim in Portuguese and Brazilian Cherry in English. This species is used in popular medicine to treat diseases such as arthritis, rheumatism and diabetes, although there have been few biological studies to verify the effectiveness of these extracts. Rapanea ferruginea is popularly known as c
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 23/09/2011
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7. The antigenotoxic activity of latex from Himatanthus articulatus
Himatanthus articulatus (Vahl) Woodson (Apocynaceae) is a native plant to the Amazon popularly used to treat ulcers, tumors, inflammations, cancer, syphilis and malaria. The aim of the present study was to investigate the in vivo genotoxic/antigenotoxic and mutagenic potential of this plant, using the comet and the micronucleus assays in mice. Female and mal
Revista Brasileira de Farmacognosia. Publicado em: 29/11/2011
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8. Evaluation of the genotoxic and antigenotoxic potential of Melissa officinalis in mice
Melissa officinalis (L.) (Lamiaceae), a plant known as the lemon balm, is native to the east Mediterranean region and west Asia. Also found in tropical countries, such as Brazil, where it is popularly known as "erva-cidreira" or "melissa", it is widely used in aqueous- or alcoholic-extract form in the treatment of various disorders. The aim was to investigat
Genetics and Molecular Biology. Publicado em: 2011
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9. Avaliação das propriedades antigenotóxicas e antioxidantes do flavonóide quercetina e dos carotenóides bixina e norbixina contra os danos no material genético e distúrbios do estado redox causados pelo cloreto de mercúrio e metilmercúrio, in vitro e in vivo / Evaluation of antigenotoxic and antioxidant properties of the flavonoid quercetin and of the carotenoid bixin and norbixin against DNA-damage and alterations of redox status induced by mercury chloride and methylmercury, in vitro and in vivo
Mercury (Hg) is one of the most hazardous metals in the environment and the major process responsible for its toxicity is oxidative damage; its organic form methylmercury (MeHg) presents the highest toxicity. The main way of exposition to Hg is through inhalation by workers occupationally exposed in several industries and/or through consumption of fishes and
Publicado em: 2011
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10. Avaliacão da atividade genotóxica e antigenotóxica de Celtis Iguanaea (JACQ.) Sargent em bactérias e camundongos / Evaluation of genotoxic activity of Celtis antigenotoxic Iguanaea (Jacq.) Sargent in bacteria and mice
Celtis iguanaea (Jacq.) Sargent é um membro da família Cannabaceae e popularmente conhecido como esporão de galo. Levantamentos etnobotânicos de plantas nativas do cerrado evidenciam que o chá das folhas de C. iguanaea é usado popularmente para dores no corpo, asma, cólicas, mádigestão, infecções urinárias, disfunções renais, como estimulante o
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 24/02/2010
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11. Avaliacão da atividade genotóxica e antigenotóxica de Celtis Iguanaea (JACQ.) Sargent em bactérias e camundongos / Evaluation of genotoxic activity of Celtis antigenotoxic Iguanaea (Jacq.) Sargent in bacteria and mice
Celtis iguanaea (Jacq.) Sargent é um membro da família Cannabaceae e popularmente conhecido como esporão de galo. Levantamentos etnobotânicos de plantas nativas do cerrado evidenciam que o chá das folhas de C. iguanaea é usado popularmente para dores no corpo, asma, cólicas, mádigestão, infecções urinárias, disfunções renais, como estimulante o
Publicado em: 2010
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12. Evaluation of beta-carotene microencapsulated antimutagenic activity in cells of rats treated with antitumor doxorubicin using micronucleus test and comet assay / Avaliação da atividade antimutagênica do beta-caroteno microencapsulado em células de ratos tratados com o antitumoral doxorrubicina empregando os ensaios de micronúcleo e cometa
Colorants are commonly used in the food industry. From natural or synthetic origin, these colorants are used in food production in order to recompense the loss of color during manufacturing and stowage processes, guarantee color uniformity and also attribute color to those colorless ones. Among natural pigments, beta-carotene (BC) has been one of the most ad
Publicado em: 2010