3 Untranslated Regions
Mostrando 1-12 de 559 artigos, teses e dissertações.
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1. Polymorphisms rs2010963 and rs833061 of the VEGF gene in polycystic ovary syndrome
SUMMARY OBJECTIVE: The polycystic ovary syndrome is the most common endocrine disorder, characterized by the dysregulation of ovarian angiogenesis. This alteration can be related to changes in the activities of the vascular endothelial growth factor (VEGF) gene. Single-nucleotide polymorphisms have been observed in the promoter, intronic, and untranslated r
Revista da Associação Médica Brasileira. Publicado em: 2022
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2. Use of homologous recombination in yeast to create chimeric bovine viral diarrhea virus cDNA clones
Abstract The open reading frame of a Brazilian bovine viral diarrhea virus (BVDV) strain, IBSP4ncp, was recombined with the untranslated regions of the reference NADL strain by homologous recombination in Saccharomyces cerevisiae, resulting in chimeric full-length cDNA clones of BVDV (chi-NADL/IBSP4ncp#2 and chi-NADL/IBSP4ncp#3). The recombinant clones were
Braz. J. Microbiol.. Publicado em: 2016-12
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3. The miR-17-92 cluster regulates FOG-2 expression and inhibits proliferation of mouse embryonic cardiomyocytes
MicroRNAs (miRNAs) have gradually been recognized as regulators of embryonic development; however, relatively few miRNAs have been identified that regulate cardiac development. A series of recent papers have established an essential role for the miRNA-17-92 (miR-17-92) cluster of miRNAs in the development of the heart. Previous research has shown that the Fr
Brazilian Journal of Medical and Biological Research. Publicado em: 2012-02
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4. Mechanisms and role of microRNA deregulation in cancer onset and progression
MicroRNAs are key regulators of various fundamental biological processes and, although representing only a small portion of the genome, they regulate a much larger population of target genes. Mature microRNAs (miRNAs) are single-stranded RNA molecules of 20-23 nucleotide (nt) length that control gene expression in many cellular processes. These molecules typ
Genetics and Molecular Biology. Publicado em: 2011
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5. AnÃlise in silico de novos potenciais polimorfismos genÃticos de risco na DoenÃa de Alzheimer em bancos de dados de Microarrays
Genomic and Proteomic studies of neurodegenerative disorders require complementary approaches to integrate the massive amount of data generated in high throughput experimental procedures. We propose a Bioinformatics pipeline in which expression studies guide the selection of candidate genes that should be screened for potential new genetic variations from a
Publicado em: 2009
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6. Characterization of the human Mov34 and PACT proteins and analyses of their interaction with dengue virus RNA / Caracterização das proteinas humanas Mov34 e PACT e analise da sua interação com o RNA do virus da dengue
O combate à dengue atualmente está limitado praticamente aos esforços de eliminação do mosquito transmissor, o Aedes aegypti, porém esta estratégia não tem se mostrado eficiente. O desenvolvimento de novos instrumentos de combate à dengue requer, portanto, maior conhecimento sobre a biologia do vírus com relação à sua interação com seus hosped
Publicado em: 2008
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7. Estudos funcionais e estruturais da proteina humana hnRNP Q/NSAP1 / Funcional and structural studies of human protein hnRNPQ
The members of the hnRNPs family (heterogenous nuclear ribonuclein proteins) play important roles in gene expression control and mRNAs metabolism. The proteins hnRNPD (AUF1) and hnRNPQ (NSAP1) were the main targets of this study. AUF1 has two RNA recognition motifs (RRM) and participates in the process of destabilization of a class of mRNAs that contain AU-r
Publicado em: 2008
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8. CUG-BP and 3'UTR sequences influence PARN-mediated deadenylation in mammalian cell extracts
Several mRNAs have been shown to exhibit distinct patterns of poly(A) shortening prior to their decay in vivo. In this study, we show that individual transcripts also demonstrate distinct patterns of deadenylation in in vitro systems derived from HeLa and Jurkat T cell cytoplasmic extracts. The major patterns observed were slow/synchronous and fast/asynchron
Genetics and Molecular Biology. Publicado em: 2007
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9. Análise comparativa do genoma de dois isolados de Cowpea aphid-borne mosaic virus (CABMV) obtidos de diferentes hospedeiros / Comparative analysis of the genome of two isolates of Cowpea aphid-borne mosaic virus (CABMV) obtained from different hosts
In Brazil and in other countries where passionfruit is grown, the viral disease known as passionfruit woodiness is a limiting factor for production. For many years this disease was associated with a single potyvirus, Passion fruit woodiness virus (PWV). However, studies conducted over the last 20 years demonstrated that two additional potyviruses, Cowpea aph
Publicado em: 2007
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10. A growth hormone-based phylogenetic analysis of euteleostean fishes including a representative species of the Atheriniformes Order, Odontesthes argentinensis
The GH (growth hormone) cDNA sequence of the marine silverside fish Odontesthes argentinensis was obtained using the RACE protocol (Rapid Amplification of cDNA Ends). The marine silverside GH cDNA sequence is 928 nucleotides long and was found to encode a polypeptide of 204 amino acids, including a signal peptide of 17 amino acids. The 5' and 3' untranslated
Genetics and Molecular Biology. Publicado em: 2003
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11. Expression of human alpha-tubulin genes: interspecies conservation of 3' untranslated regions.
To examine the sequence complexity and differential expression of human alpha-tubulin genes, we constructed cDNA libraries from two unrelated tissue types (epidermis and fetal brain). The complete sequence of a positively hybridizing alpha-tubulin clone from each library is described. Each is shown to represent an abundantly expressed gene from fetal brain a
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12. UTRdb: a specialized database of 5'- and 3'-untranslated regions of eukaryotic mRNAs.
The important role the untranslated regions of eukaryotic mRNAs may play in gene regulation and expression is now widely acknowledged. For this reason we developed UTRdb, a specialized database of 5'- and 3'-untranslated sequences of eukaryotic mRNAs cleaned from redundancy. UTRdb entries are enriched with specialized information not present in the primary d