4 Aminopyridines
Mostrando 1-8 de 8 artigos, teses e dissertações.
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1. Síntese de novos derivados de 1-(7-cloro-4- Quinolinil)tiossemicarbazidas e Semicarbazidas como potencias agentes Antibacterianos e antiparasitários
This work, entitled Synthesis of novel derivatives of 1-(7-chloro-4- quinolinyl)thiosemicarbazides and semicarbazides as potencial antibacterial and antiparasitic agents describes the synthesis of new derivatives of 1-(7-chloro-4- quinolinyl)thiosemicarbazides and semicarbazides, N-1-substituted pyridine derivatives were also prepared and their evaluation as
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 18/07/2011
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2. Microwave-assisted reaction of 2,3-dichloronaphthoquinone with aminopyridines
Piridilaminonaftoquinonas foram preparadas a partir da reação de 2,3-dicloro-1,4-naftoquinona e aminopiridinas empregando irradiação de microondas. O uso de microondas diminuiu os tempos de reação e forneceu os melhores rendimentos em todos os casos. As substâncias preparadas foram avaliadas em células de câncer de mama (MCF-7).
Journal of the Brazilian Chemical Society. Publicado em: 2009
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3. Sobre o emprego da 4-aminopiridina, 3.4-diaminopiridina e da neostigmina como antagonista de curare : estudo comparativo
The effects ot 4-aminopyridine (1; 5 e 25 ug/ml), 3.4-diaminopyridine (1; 5 and 25 ug/ml) as well as the association of the drugs with neostigmine, were investigated using the noncurarized rat s phrenic nerve-hemidiaphragm preparations and d-tubocurarine-blocked preparations. The preparations were treated by two different procedures; indirect estimulation by
Publicado em: 1981
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4. Reação de difenilciclopropenona com 2-aminopiridinas e compostos relacionados
Diphenylcyclopropenone reacts with 2-aminopyridines in diethyl ether to give cis-3,4-dihidro-3,4-diphenyl-2H-pyrido [1,2-a] pyrimidin-2-ones and N(2-pyridil) cis-2,3-diphenylacrylamides. The same reaction in methanol leads to trans-pyridopyrimidin-2-ones and crylamides. In methanol the cis-pyridopyrimidin-2-ones isomerize to trans-pyridopyrimidin-2-ones and
Publicado em: 1975
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5. A preclinical evaluation of aminopyridines as putative therapeutic agents in the treatment of botulism.
4-Aminopyridine and 3,4-diaminopyridine were evaluated for their abilities to delay the onset of paralysis due to botulinum neurotoxin types A, B, and E. Experiments were done on phrenic nerve-hemidiaphragm preparations excised from mice. At a concentration that produced an enhancement in muscle twitch amplitude, 4-aminopyridine and 3,4-diaminopyridine delay
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6. On the active form of 4-aminopyridine: block of K+ currents in rabbit Schwann cells.
1. The blocking action of 4-aminopyridine (4-AP) on the outward potassium currents evoked by depolarization of rabbit Schwann cells in short-term primary culture was studied with the whole-cell configuration of the patch-clamp method. 2. We have determined the apparent equilibrium dissociation constant, K, for the action of 4-AP to block potassium currents a
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7. Slowly inactivating potassium channels induced in Xenopus oocytes by messenger ribonucleic acid from Torpedo brain.
Poly(A+) messenger RNA was extracted from the electric lobe and medulla of Torpedo and injected into oocytes of Xenopus laevis. The synthesis and processing of proteins coded by the injected messenger RNA led to the incorporation of voltage-activated channels in the oocyte membrane. A large, well maintained outward current was recorded from injected oocytes
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8. Electrical and morphological factors influencing the depolarizing after-potential in rat and lizard myelinated axons.
1. Intra-axonal recording and electron microscopy were applied to intramuscular myelinated axons in lizards and rats to investigate factors that influence the amplitude and time course of the depolarizing after-potential. 2. Depolarizing after-potentials in lizard axons had larger peak amplitudes and longer half-decay times than those recorded in rat axons (