8 Hydroxy 2 Deoxyguanosine
Mostrando 1-12 de 32 artigos, teses e dissertações.
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1. The effectiveness of berberine on noise-induced hearing loss: a rat model
SUMMARY OBJECTIVE: Noise-induced hearing loss is a preventable form of hearing loss that has serious social and economic impacts. This study aimed to investigate the protective effect of berberine, a potent antioxidant and anti-inflammatory agent, against Noise-induced hearing loss. METHODS: After applying distortion product otoacoustic emission, 28 female
Revista da Associação Médica Brasileira. Publicado em: 2022
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2. Effects of Physical Training on the Myocardium of Oxariectomized LDLr Knockout Mice: MMP 2/9, Collagen I/III, Inflammation and Oxidative Stress
Resumo Fundamento: O surgimento da doença cardíaca coronariana aumenta com a menopausa, inatividade física e dislipidemia. Sabe-se que o treinamento físico promove a melhora das funções cardiovasculares Objectivo: Investigar os efeitos do treinamento físico aeróbico sobre o ventrículo esquerdo em camundongos LDL knockout ovariectomizadas. Método
Arq. Bras. Cardiol.. Publicado em: 21/10/2019
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3. Inhibition of growth of U87MG human glioblastoma cells by Usnea longissima Ach.
Abstract: Herbal medicines are efficient to reduce side effects in the fight against glioblastoma, which plays a critical role within brain cancer species. The recent studies designated for testing the effects of lichens that have shown numerous anticancer activities on glioblastoma so far. In the present study, different concentrations of water extract obta
An. Acad. Bras. Ciênc.. Publicado em: 07/10/2019
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4. The compound, diallyl disulfide, enriched in garlic, prevents the progression of doxorubicin-induced nephropathy
Abstract The main medicinal property of garlic is mostly attributed to its organosulfur compounds, of which the oil-soluble diallyl disulfide (DADS) is the principal component of distilled garlic oil. Nuclear factor erythroid 2-related factor 2 (Nrf2) is an important cellular regulator in response to oxidative stress. This study assessed the possible protect
Food Sci. Technol. Publicado em: 27/05/2019
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5. Evaluating clinical and laboratory effects of ozone in non-surgical periodontal treatment: a randomized controlled trial
Abstract Objective: This study aims to evaluate the clinical and biochemical (oxidative stress and pro-inflammatory mediators) effects of the gaseous ozone use accompanied by scaling and root planning (SRP) in periodontal treatment. Material and Methods: The study population consisted of 40 patients with chronic periodontitis (CP) randomly sorted into two
J. Appl. Oral Sci.. Publicado em: 14/01/2019
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6. Effect of the tocotrienol-rich fraction on the lifespan and oxidative biomarkers in Caenorhabditis elegans under oxidative stress
OBJECTIVE: This study was performed to determine the effect of the tocotrienol-rich fraction on the lifespan and oxidative status of C. elegans under oxidative stress. METHOD: Lifespan was determined by counting the number of surviving nematodes daily under a dissecting microscope after treatment with hydrogen peroxide and the tocotrienol-rich fraction. T
Clinics. Publicado em: 2013-05
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7. O cha verde (Camellia sinensis) atenua a nefropatia atraves da redução da expressão da subunidade NOX-4 da ND(P)H oxidase no diabetes mellitus experimental / Green tea (Camellia sinensis) attenuates nephropath by downregulating Nox4 NADPH oxidase in experimental diabetes mellitus
It has been suggested that green tea (GT) has beneficial properties in the treatment or prevention of human disease. The major biological mechanisms of action of GT are being attributed to its antioxidant properties. Several lines of evidence suggest that oxidative stress contributes to the pathogenesis of diabetic nephropathy. The effect of GT on diabetic n
Publicado em: 2008
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8. Inibição de danos em DNA e alteração da expressão gênica em ratos Wistar tratados com as hortaliças couve e repolho (Brassica oleracea) e submetidos à hepatocarcinogênese química / Inhibition in DNA damages and differential gene expression in Wistar rats treated with kale and cabbage (Brassica oleracea) and submitted to chemical hepatocarcinogenesis
O câncer é a segunda maior causa de morte no mundo, sendo responsável por aproximadamente 7,6 milhões de óbitos. Entretanto, pesquisadores alertam para uma associação inversa entre o consumo de frutas e hortaliças e o desenvolvimento de neoplasias, desta forma a organização mundial da saúde sugere, dentre outras medidas para controle do câncer, o
Publicado em: 2007
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9. A hipertensão arterial exacerba o estresse oxidativo em retina de ratos experimentalmente diabeticos / Arterial hypertension exarcebates oxidative stress in retina of experimentally diabetic rats
The presence of arterial hypertension in patients with diabetes mellitus (DM) is identified as the most important independent risk factor for progression of diabetic retinopathy (DR). Independently, diabetes and hypertension increase oxidative stress in the retina both humans and animals. However, the effect of the combination of both hypertension and DM in
Publicado em: 2007
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10. Avaliação morfológica e de biomarcadores em epitélio respiratório e olfatório de cães da cidade de São Paulo e sua relação com o índice de material particulado (PM10) no ar atmosférico / Morphologic evaluation of biomarkers in respiratory and olfactory epithelium of dogs of the city of São Paulo and its relation with the index of particulado material (PM10) in atmospheric air
A poluição atmosférica interfere diretamente com a saúde populacional. Há evidências de que os animais de companhia representam sentinelas para fatores ambientais onde o homem e os demais animais estariam expostos. Animais podem ser usados como indicadores de poluição ambiental. O desenvolvimento industrial e urbano tem originado, em todo o mundo, um
Publicado em: 2006
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11. Urinary 8-hydroxy-2'-deoxyguanosine as a biological marker of in vivo oxidative DNA damage.
DNA is subject to constant oxidative damage from endogenous oxidants. The oxidized DNA is continuously repaired and the oxidized bases are excreted in the urine. A simple routine analytical procedure is described for urinary 8-hydroxy-2'-deoxyguanosine, an oxidative DNA damage adduct, as an indicator of oxidative damage in humans and rodents. This adduct was
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12. Photooxidation of d(TpG) by phthalocyanines and riboflavin. Isolation and characterization of dinucleoside monophosphates containing the 4R* and 4S* diastereoisomers of 4,8-dihydro-4-hydroxy-8-oxo-2'-deoxy-guanosine.
Phthalocyanine mediated photosensitization of 2'-deoxyguanosine (dG) in oxygen saturated aqueous solution has previously been shown to result in the addition of molecular oxygen to the guanine base generating the 4R* and 4S* diastereoisomers of 4,8-dihydro-4-hydroxy-8-oxo-2'-deoxyguanosine (dO) (the asterisk denotes unambiguous assignment of the 4R and 4S di