9 O Acetyl Gd3
Mostrando 1-7 de 7 artigos, teses e dissertações.
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1. Functional role of a specific ganglioside in neuronal migration and neurite outgrowth
Cell migration occurs extensively during mammalian brain development and persists in a few regions in the adult brain. Defective migratory behavior of neurons is thought to be the underlying cause of several congenital disorders. Knowledge of the dynamics and molecular mechanisms of neuronal movement could expand our understanding of the normal development o
Brazilian Journal of Medical and Biological Research. Publicado em: 2003-08
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2. Functional role of a glycolipid in directional movements of neurons
A migração de neurônios de seus sítios de origem a seus destinos finais é uma etapa universal e crítica na formação da complexa estrutura do sistema nervoso. Admite-se que o processo migratório seja governado, em parte, por sequências de sinais definidas genetica e epigeneticamente que são interpretadas pelas células migrantes. Os mecanismos mole
Anais da Academia Brasileira de Ciências. Publicado em: 2001-06
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3. The 9-O-acetyl GD3 gangliosides are expressed by migrating chains of subventricular zone neurons in vitro
Neurons from the anterior subventricular zone (SVZ) of the cerebral cortex migrate tangentially to become interneurons in the olfactory bulb during development and in adult rodents. This migration was defined as neuronophilic, independent of a radial glial substrate. The cortical SVZ and the rostral migratory stream to the olfactory bulb were shown to be ric
Brazilian Journal of Medical and Biological Research. Publicado em: 2001-05
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4. Function of ganglioside 9-O-acetyl GD3 in neuronal migration
Anais da Academia Brasileira de Ciências. Publicado em: 2000-09
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5. O-acetylation of a cell-surface carbohydrate creates discrete molecular patterns during neural development.
The cell-surface antigen detected by the monoclonal antibody JONES is expressed in the retina and a number of other central nervous system regions of the rat during the latter part of embryonic development and the early postnatal period. In addition to the expression on certain neuroblast populations it is found on some but not all axons and is also expresse
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6. Expression cloning and characterization of a cDNA encoding a novel membrane protein required for the formation of O-acetylated ganglioside: A putative acetyl-CoA transporter
By expression cloning using COS-1 cells stably transfected with GD3-synthase (COS-1/GD3+) as a recipient cell line, we have isolated a cDNA, termed AT-1, encoding a novel protein required for the formation of O-acetylated (Ac) gangliosides. The cDNA encodes a protein with multitransmembrane spanning domains with a leucine zipper motif. It consists of 549 ami
The National Academy of Sciences of the USA.
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7. Serological response patterns of melanoma patients immunized with a GM2 ganglioside conjugate vaccine.
Gangliosides, such as GM2, GD2, GD3, and 9-O-acetyl GD3, are receiving attention as targets for antibody-based and vaccine-based therapies of melanoma. GM2 appears to be a particularly immunogenic ganglioside in humans, as indicated by the presence of naturally occurring IgM anti-GM2 antibodies in approximately 5% of humans and the fact that immunization wit