Accessory Gene Regulator
Mostrando 1-12 de 61 artigos, teses e dissertações.
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1. The accessory gene regulator (agr) controls Staphylococcus aureus virulence in a murine intracranial abscesses model
Background: Intracranial abscesses are associated with high mortality. Staphylococcus aureus is one of the main pathogens that cause intracranial infection. Until now, there is no report to identify the key effectors of S. aureus during the intracranial infection. Methods: The murine intracranial abscesses model induced by S. aureus was constructed. The v
Braz J Infect Dis. Publicado em: 2014-09
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2. Comparative analysis of agr groups and virulence genes among subclinical and clinical mastitis Staphylococcus aureus isolates from sheep flocks of the Northeast of Brazil
Staphylococcus aureus is one of the most frequent mastitis causative agents in small ruminants. The expression of most virulence genes of S. aureus is controlled by an accessory gene regulator (agr)locus. This study aimed to ascertain the prevalence of the different agr groups and to evaluate the occurrence of encoding genes for cytotoxin, adhesins and toxin
Braz. J. Microbiol.. Publicado em: 2013
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3. Occurrence of methicillin resistant Staphylococcus aureus (MRSA) among clinical samples in tehran-iran and its correlation with polymorphism of specific accessory gene regulator (AGR) groups
Methicillin-Resistant Staphylococcus aureus (MRSA) is responsible for an increasing number of serious hospital and community acquired infections. Virulence gene expression in Staphylococcus aureus is orchestrated by regulators such as the accessory gene regulator (agr). Staphylococcal strains are divided into four major agr groups (agrI-IV) on the basis of a
Brazilian Journal of Microbiology. Publicado em: 2012-06
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4. Avaliação da funcionalidade do locus acessory gene regulator (agr) em cepas de «Staphylococcus aureus» brasileiras com suscetibilidade reduzida aos glicopeptídeos / Characterisation of the accessory gene regulator in Brazilian Staphylococcus aureus strains with reduced susceptibility to vancomycin.
The treatment of staphylococcal infections has lately been a strenuous undertaking due to the resistance of Staphylococcus aureus to multiple antibiotics. The antimicrobial drug of choice for the treatment of methicillin resistant S. aureus (MRSA) is the glycopeptide vancomycin. Since the first isolation of S. aureus with reduced susceptibility to vancomycin
Publicado em: 2006
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5. Genotipic characterization of virulence factors and agr of Staphylococcus aureus oxacillin sensitive / Caracterização genotípica dos fatores de virulência e seu regulador "agr" em cepas de "Staphylococcus aureus" sensíveis à oxacilina
The capacity of the Staphylococcus aureus to escape from the immune system of the host is conferred to the existence of some exotoxins, which are codified by accessory genes. The expression of the genes of exotoxins is controlled by regulators, such as agr (acessory gene regulator), being identified four different types of this regulator. In this study, it h
Publicado em: 2006
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6. Staphylococcal enterotoxin A gene (sea) expression is not affected by the accessory gene regulator (agr).
The goal of this work was to determine whether staphylococcal enterotoxin type A gene (sea) expression is regulated by an accessory gene regulator (agr). The Tn551 insertionally inactivated agr allele of Staphylococcus aureus ISP546 was transferred to three Sea+ S. aureus strains. Each of the Agr- strains produced as much staphylococcal enterotoxin A (SEA) a
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7. Alkaline pH decreases expression of the accessory gene regulator (agr) in Staphylococcus aureus.
The effect of alkaline pH on expression of the accessory gene regulator (agr) in Staphylococcus aureus was examined. agr, a global regulator, affects the expression of numerous exoproteins, including alpha-hemolysin, toxic shock syndrome toxin 1, protein A, and staphylococcal enterotoxins types B, C, and D. agr contains two major, divergent transcripts, desi
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8. Repression of the Staphylococcus aureus Accessory Gene Regulator in Serum and In Vivo
Subgenomic DNA microarrays were employed to evaluate the expression of the accessory gene regulator (agr locus) as well as multiple virulence-associated genes in Staphylococcus aureus. Gene expression was examined during growth of S. aureus in vitro in standard laboratory medium and rabbit serum and in vivo in subcutaneous chambers implanted in either nonimm
American Society for Microbiology.
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9. Role of SarA in Virulence Determinant Production and Environmental Signal Transduction in Staphylococcus aureus
The staphylococcal accessory regulator (encoded by sarA) is an important global regulator of virulence factor biosynthesis in Staphylococcus aureus. To further characterize its role in virulence determinant production, an sarA knockout mutant was created by insertion of a kanamycin antibiotic resistance cassette into the sarA gene. N-terminal sequencing of e
American Society for Microbiology.
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10. Accessory Gene Regulator Control of Staphyloccoccal Enterotoxin D Gene Expression†
The quorum-sensing system of Staphylococcus aureus, the accessory gene regulator (Agr) system, is responsible for increased transcription of certain exoprotein genes and decreased transcription of certain cell wall-associated proteins during the postexponential phase of growth. This regulation is important for virulence, as evidenced by a reduction in virule
American Society for Microbiology.
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11. Steady-state staphylococcal enterotoxin type C mRNA is affected by a product of the accessory gene regulator (agr) and by glucose.
The effects of the accessory gene regulator (agr) and glucose on staphylococcal enterotoxin type C (SEC) gene (sec+) expression were examined. For the agr studies, a Tn551 insertionally inactivated agr was transferred into two different sec+ Staphylococcus aureus strains. Western blot (immunoblot) analysis showed that each of the sec+ Agr- derivatives produc
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12. Glucose and nonmaintained pH decrease expression of the accessory gene regulator (agr) in Staphylococcus aureus.
The effect of glucose on accessory gene regulator (agr) expression in Staphylococcus aureus was examined. agr is a global regulator that affects the expression of numerous genes, including those for some factors implicated in virulence, such as toxic shock syndrome toxin 1, alpha-hemolysin, and protein A. The agr locus determines two divergent transcripts, d