Acido Acromelico
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1. Reação de arilação de Heck regio e estereosseletiva da 3-desidroprolina com sais de arildiazonio : aplicação na sintese total de analogos neuroexcitatorios do acido acromelico / Regio and stereoselective Heck arylation of 3-dehydroprolines with aryldiazonium salts. Total synthesis of the neuroexcitatory acromelic acid analogues
The Heck arylation of chiral 3-dehydroprolines using various aryldiazonium salt resulted in the formation of a series of 4-aryl-dehydroprolines of potential biological interest. The application of aryldiazonium salt in this arylation reaction offers several advantages over traditional Heck reactions such as mild reactions conditions of phosphine-free conditi
Publicado em: 2006