Active Pharmaceutical Ingredients
Mostrando 1-12 de 22 artigos, teses e dissertações.
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1. Avanços recentes na síntese do Remdesivir, Molnupiravir (EIDD-2801) e Tenofovir: moléculas promissoras no tratamento da COVID-19
RECENT ADVANCES IN THE SYNTHESIS OF REMDESIVIR, MOLNUPIRAVIR (EIDD-2801) AND TENOFOVIR: PROMISING MOLECULES IN THE TREATMENT OF COVID-19. The search for new treatments to contain the Covid-19 pandemic has highlighted the importance of nucleoside antivirals, such as Remdesivir, Tenofovir and Molnupiravir. Over the last two years, these molecules have been int
Química Nova. Publicado em: 2022
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2. EVOLUÇÃO DA LEGISLAÇÃO E DAS TÉCNICAS ANALÍTICAS APLICADAS A ESTUDOS DE ESTABILIDADE DE INSUMOS E PRODUTOS FARMACÊUTICOS
Stability is an important parameter to evaluate the quality, safety and efficacy of drug substances and pharmaceutical products. The stability studies aim to determine the ability of a formulation to maintain its specifications, in order to establish shelf life and recommended storage conditions. Despite the extensive relevance, until the 1980’s the stabil
Quím. Nova. Publicado em: 20/07/2020
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3. Immunogenicity and safety of the combined vaccine for measles, mumps, and rubella isolated or combined with the varicella component administered at 3-month intervals: randomised study
BACKGROUND Field testing required to license the combined measles, mumps, and rubella (MMR) vaccine must take into account the current recommendation of the vaccine in Brazil: first dose at 12 months and second dose at 15 months of age in combination with a varicella vaccine. OBJECTIVES This study aimed to evaluate the clinical consistency, immunogenicit
Mem. Inst. Oswaldo Cruz. Publicado em: 07/03/2019
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4. Using Bar Infrared Spectra and Coincidence Indexes to Study the Diversity of Solid Cyanuric Acid Structures
A general method was developed for studying the diversity of individuals in a population based on the diversity of infrared spectra of solid cyanuric acid analytes obtained from various reactions of trichlorocyanuric acid. This method first generates infrared bar spectra for the analytes and then measures the coincidence and continence among pairs of the spe
J. Braz. Chem. Soc.. Publicado em: 2018-07
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5. Impact of continuous flow chemistry in the synthesis of natural products and active pharmaceutical ingredients
ABSTRACT We present a comprehensive review of the advent and impact of continuous flow chemistry with regard to the synthesis of natural products and drugs, important pharmaceutical products and definitely responsible for a revolution in modern healthcare. We detail the beginnings of modern drugs and the large scale batch mode of production, both chemical an
An. Acad. Bras. Ciênc.. Publicado em: 2018
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6. Analysis of spironolactone polymorphs in active pharmaceutical ingredients and their effect on tablet dissolution profiles
ABSTRACT Spironolactone (SPR) is a steroidal drug administered as a potassium-sparing diuretic for high blood pressure treatment. The drug shows incomplete gastrointestinal absorption due to its poor aqueous solubility. The physicochemical properties of SPR in crystal forms I and II suggest that differences in their aqueous solubility may lead to a lack of b
Braz. J. Pharm. Sci.. Publicado em: 2016-12
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7. Ultra-fast determination of scopolamine, orphenadrine, mepyramine, caffeine, dipyrone, and ascorbic acid by capillary electrophoresis with capacitively coupled contactless conductivity detection
In this paper, we present a simple and low-cost capillary electrophoresis method for ultra-fast determination of active ingredients present in three different pharmaceutical formulations: (i) scopolamine (SCO) and dipyrone (DIP); (ii) orphenadrine (ORP), caffeine (CAF) and DIP; (iii) mepyramine (MEP), CAF, DIP, and ascorbic acid (AA). The proposed method is
J. Braz. Chem. Soc.. Publicado em: 2014-05
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8. Validação de método quantitativo por RMN de ¹H para análises de formulações farmacêuticas
The need for effective and reliable quality control in products from pharmaceutical industries renders the analyses of their active ingredients and constituents of great importance. This study presents the theoretical basis of ¹H NMR for quantitative analyses and an example of the method validation according to Resolution RE Nº 899 by the Brazilian Nationa
Quím. Nova. Publicado em: 2013
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9. DESENVOLVIMENTO, OTIMIZAÇÃO E VALIDAÇÃO DE METODOLOGIAS POR ELETROFORESE CAPILAR PARA ANÁLISE DE FÁRMACOS UTILIZADOS NO TRATAMENTO DA TUBERCULOSE
The main focus of this thesis was the development, optimization and validation of analytical methodologies for analysis of pharmaceutical preparations used for tuberculosis treatment, which contain as active ingredients, ethambutol (ETB), isoniazid (ISO), rifampicin (RIF) and pyrazinamide (PYR) isolated or in association. Two analytical methodologies for ETB
Publicado em: 2010
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10. APLICAÇÃO DO ENSAIO DE DISSOLUÇÃO NA AVALIAÇÃO DA QUALIDADE DE MEDICAMENTOS FITOTERÁPICOS À BASE DE Passiflora sp / APPLICATION OF TEST TO EVALUATE THE SOLUTION QUALITY OF HERBAL MEDICINES BASED Passiflora sp
Phytomedicines must to have as active ingredients only products derived from plants. The quality control of these medicines has not yet properly established criteria even with the growing consumption of these drugs worldwide. Among the assays to evaluate the quality there is the test of dissolution, used to examine the release of the active principle from a
Publicado em: 2008
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11. APLICAÇÃO DO ENSAIO DE DISSOLUÇÃO NA AVALIAÇÃO DA QUALIDADE DE MEDICAMENTOS FITOTERÁPICOS À BASE DE Passiflora sp / APPLICATION OF TEST TO EVALUATE THE SOLUTION QUALITY OF HERBAL MEDICINES BASED Passiflora sp
Phytomedicines must to have as active ingredients only products derived from plants. The quality control of these medicines has not yet properly established criteria even with the growing consumption of these drugs worldwide. Among the assays to evaluate the quality there is the test of dissolution, used to examine the release of the active principle from a
Publicado em: 2008
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12. APPLICATION OF TEST TO EVALUATE THE SOLUTION QUALITY OF HERBAL MEDICINES BASED Passiflora sp / APLICAÇÃO DO ENSAIO DE DISSOLUÇÃO NA AVALIAÇÃO DA QUALIDADE DE MEDICAMENTOS FITOTERÁPICOS À BASE DE Passiflora sp
Phytomedicines must to have as active ingredients only products derived from plants. The quality control of these medicines has not yet properly established criteria even with the growing consumption of these drugs worldwide. Among the assays to evaluate the quality there is the test of dissolution, used to examine the release of the active principle from a
Publicado em: 2008