Acyclonucleoside
Mostrando 1-3 de 3 artigos, teses e dissertações.
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1. Síntese de Novos Nucleosídeos Quinolônicos não Naturais como Potenciais Agentes Antivirais / Synthesis of New Quinolonics Nucleosides no Natural by Antivirals Potential Agents
The interesting biological activities of synthetic quinoline derivatives as antibacterial and antiviral agents urged many research groups to construct numerous analogues of such compounds. Since the discovery of acyclovir as a potent and selective antiherpes virus agent, considerable interest has been focused in the synthesis of novel acyclonucleoside analog
Publicado em: 2003
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2. Mode of action of 9-(4-hydroxy-3-hydroxymethylbut-1-yl)guanine (BRL 39123) against herpes simplex virus in MRC-5 cells.
The metabolism and mode of action of 9-(4-hydroxy-3-hydroxymethylbut-1-yl)guanine (BRL 39123) were studied in herpes simplex virus type 1 (HSV-1)-infected and uninfected MRC-5 cells and compared with those of acyclovir. In uninfected cells incubated with 10 microM acyclonucleoside for 4 h, no phosphorylation of either BRL 39123 or acyclovir was detected. In
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3. Single base extension (SBE) with proofreading polymerases and phosphorothioate primers: improved fidelity in single-substrate assays
Model single base extension (SBE) genotyping reactions with individual deoxy-, dideoxy- and acyclonucleoside triphosphates are monitored by MALDI-TOF mass spectrometry. Three non-proofreading DNA polymerases display remarkably high misincorporation (up to 64% of correct incorporation) when extending primers with single substrates at saturating concentrations
Oxford University Press.