Adherens Junctions
Mostrando 1-12 de 103 artigos, teses e dissertações.
-
1. Glycans expression and their involvement with the loss of stability of adherens junctions in colorectal cancer cells / Expressão de glicanos e seu envolvimento com a perda da estabilidade das junções aderentes em células de câncer colo-retal
A junção aderente (JA) é um dos principais componentes do complexo juncional apical. Esta juncão é um complexo multiprotéico em que a E-caderina, uma glicoproteína transmembrana, atua como principal mediadora da adesão célula-célula. Sua ancoragem ao citoesqueleto de actina ocorre via proteínas da família das cateninas. Modificações pós-traduc
Publicado em: 2009
-
2. Remodeling of dystrophin-glycoprotein complex, intercalated disk proteins, and contractile proteins in the hearts of mice subjected to sepsis induced by cecal ligation and puncture. / Remodelamento do complexo de glicoproteínas associadas à distrofina, do disco intercalar e das proteínas contráteis no coração de camundongos submetidos à sépsis induzida por ligação e perfuração do ceco
Sepsis and septic shock represent a complex syndrome of systemic inflammatory response, with multiple physiological and immunological abnormalities, commonly caused by bacterial infection. The most important consequence of the response is the involvement of many organs and tissues. Cardiac dysfunction, caused by impairment in myocardial contractility, has be
Publicado em: 2008
-
3. Estrutura e ultra-estrutura das glândulas salivares de Cimex hemipterus (Fabricius, 1803) (Hemiptera: Cimicidae) / Structure and ultrastructure of the salivary glands of Cimex hemipterus (Fabricius, 1803) (Hemiptera: Cimicidae)
Cimex hemipterus is a hematophagous insect that can be an experimental host of the Trypanosoma cruzi and may play a role as vector of Chagas disease. This work analyzed the structure of the salivary glands of C. hemipterus. Adults were dissected and the salivary glands were analyzed in light microscopy and transmission electron microscopy. The secretory port
Publicado em: 2007
-
4. DLG-1 Is a MAGUK Similar to SAP97 and Is Required for Adherens Junction Formation
Cellular junctions are critical for intercellular communication and for the assembly of cells into tissues. Cell junctions often consist of tight junctions, which form a permeability barrier and prevent the diffusion of lipids and proteins between cell compartments, and adherens junctions, which control the adhesion of cells and link cortical actin filaments
The American Society for Cell Biology.
-
5. The Protein Tyrosine Phosphatase Pez Is a Major Phosphatase of Adherens Junctions and Dephosphorylates β-Catenin
Cell-cell adhesion regulates processes important in embryonal development, normal physiology, and cancer progression. It is regulated by various mechanisms including tyrosine phosphorylation. We have previously shown that the protein tyrosine phosphatase Pez is concentrated at intercellular junctions in confluent, quiescent monolayers but is nuclear in c
The American Society for Cell Biology.
-
6. Activation of Both MAP Kinase and Phosphatidylinositide 3-Kinase by Ras Is Required for Hepatocyte Growth Factor/Scatter Factor–induced Adherens Junction Disassembly
Hepatocyte growth factor/scatter factor (HGF/SF) stimulates the motility of epithelial cells, initially inducing centrifugal spreading of colonies followed by disruption of cell–cell junctions and subsequent cell scattering. In Madin–Darby canine kidney cells, HGF/SF-induced motility involves actin reorganization mediated by Ras, but whether Ras and down
The American Society for Cell Biology.
-
7. E-cadherin controls adherens junctions in the epidermis and the renewal of hair follicles
E-cadherin is thought to mediate intercellular adhesion in the mammalian epidermis and in hair follicles as the adhesive component of adherens junctions. We have tested this role of E-cadherin directly by conditional gene ablation in the mouse. We show that postnatal loss of E-cadherin in keratinocytes leads to a loss of adherens junctions and altered epider
Oxford University Press.
-
8. Crk Adapter Proteins Promote an Epithelial–Mesenchymal-like Transition and Are Required for HGF-mediated Cell Spreading and Breakdown of Epithelial Adherens Junctions
Activation of the Met receptor tyrosine kinase through its ligand, hepatocyte growth factor (HGF), promotes an epithelial–mesenchymal transition and cell dispersal. However, little is known about the HGF-dependent signals that regulate these events. HGF stimulation of epithelial cell colonies leads to the enhanced recruitment of the CrkII and CrkL adapter
The American Society for Cell Biology.
-
9. Disruption of Adherens Junctions Liberates Nectin-1 To Serve as Receptor for Herpes Simplex Virus and Pseudorabies Virus Entry
Nectin-1, a cell adhesion molecule belonging to the immunoglobulin superfamily, can bind to virion glycoprotein D (gD) to mediate entry of herpes simplex viruses (HSV) and pseudorabies virus (PRV). Nectin-1 colocalizes with E-cadherin at adherens junctions in epithelial cells. The disruption of cell junctions can result in the redistribution of nectin-1. To
American Society for Microbiology.
-
10. Contactus adherens, a special type of plaque-bearing adhering junction containing M-cadherin, in the granule cell layer of the cerebellar glomerulus.
In the glomeruli of the granule cell layer of mammalian cerebellum, neuronal extensions are interconnected by numerous small, nearly isodiametric (diameters up to 0.1 micron), junctions previously classified as puncta adherentia related to the vinculin-containing, actin microfilament-anchoring junctions of the zonula adherens of epithelial and certain other
-
11. Rho-stimulated Contractility Contributes to the Fibroblastic Phenotype of Ras-transformed Epithelial Cells
Oncogenic transformation of cells alters their morphology, cytoskeletal organization, and adhesive interactions. When the mammary epithelial cell line MCF10A is transformed by activated H-Ras, the cells display a mesenchymal/fibroblastic morphology with decreased cell–cell junctions but increased focal adhesions and stress fibers. We have investigated whet
The American Society for Cell Biology.
-
12. Cleavage of β-Catenin and Plakoglobin and Shedding of VE-Cadherin during Endothelial Apoptosis: Evidence for a Role for Caspases and Metalloproteinases
Growth factor deprivation of endothelial cells induces apoptosis, which is characterized by membrane blebbing, cell rounding, and subsequent loss of cell–matrix and cell–cell contacts. In this study, we show that initiation of endothelial apoptosis correlates with cleavage and disassembly of intracellular and extracellular components of adherens junction
The American Society for Cell Biology.