Adrenocortical Hormones
Mostrando 1-12 de 17 artigos, teses e dissertações.
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1. Mecanismos moleculares do efeito citotoxico da dexametasona em linhagens de celulas beta e ilhotas pancreaticas / Molecular mechanisms of the cytotoxic effect of dexamethasone in insulin producing cells and pancreatic islets
Introdução/Objetivos. A produção de espécies reativas de oxigênio (EROs) faz parte de diversos processos fisiológicos. Nos últimos anos, o aumento de EROs têm sido associado ao desenvolvimento de diversas doenças, dentre elas o Diabetes Mellitus Tipo 2. As células beta pancreáticas são notadamente mais suscetíveis ao estresse oxidativo devido a
Publicado em: 2009
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2. Análise da ação do ACTH e do peptídeo N-terminal da POMC na proliferação, morte celular e na expressão das proteínas de genes de resposta secundária na supra-renal de ratos hipofisectomisados ou tratados com dexametasona. / Analysis of ACTH and the peptide N-terminal POMC in proliferation, cell death, and expression of secondary response genes in adrenal glands of hypophysectomized or dexamethasone treated rats.
Different experimental models have been used to study the trophic action of ACTH in adrenal, which seems to be important in proliferation and cell death in vivo. This hypothesis was tested using hypophysectomized or dexamethasone treated rats, and through IHC we evaluate: 1-the BrdU incorporation in different adrenal cortex zone after i.p. of ACTH, FGF2 or N
Publicado em: 2008
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3. Prolactin induces adrenal hypertrophy
Although adrenocorticotropic hormone is generally considered to play a major role in the regulation of adrenal glucocorticoid secretion, several reports have suggested that other pituitary hormones (e.g., prolactin) also play a significant role in the regulation of adrenal function. The aim of the present study was to measure the adrenocortical cell area and
Brazilian Journal of Medical and Biological Research. Publicado em: 2004-02
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4. Clonagem do Receptor de ACTH de células adrenocorticais Y-1 de camundongo e expressão em fibroblastos 3T3 e células de AR-1 para elucidação de vias de transdução de sinal / Cloning of ACTH receptor from mouse Y1 adrenocortical cells and expression in to mouse 3T3 fibroblasts and AR-1 cells for the study of signal transduction pathways.
The adrenocorticotropic hormone, ACTH, regulates both function and proliferation of adrenocortical cells binding to a specific receptor, ACTHR, which belongs to superfamily of GPCR (G-protein coupled receptors). ACTHR was cloned a few years ago, but the molecular mechanisms underlying the mitogenic and anti-mitogenic actions of ACTH remain unknown, whose elu
Publicado em: 2001
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5. THE EFFECT OF THE CHRONIC ADMINISTRATION OF ADRENAL MEDULLARY HORMONES TO MAN ON ADRENOCORTICAL FUNCTION AND THE RENAL EXCRETION OF ELECTROLYTES
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6. THE ABILITY OF CERTAIN ADRENOCORTICAL HORMONES TO POTENTIATE THE VASOCONSTRICTOR ACTION OF NOR-ADRENALINE ON THE CONJUNCTIVAL VESSELS IN THE RABBIT AND IN MAN*
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7. Steroidogenic potential of lyophilized mitochondria from bovine adrenocortical tissue.
When incubated with [3H]cholesterol, a bovine adrenocortical mitochondrial pellet obtained by centrifugation at 12,000 x g yielded, as expected, only the C21O2 metabolites progesterone and pregnenolone. However, the steroidogenic potential of the 12,000 x g pellet fraction was augmented significantly by lyophilization. After lyophilization, the 12,000 x g pe
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8. Regulation of corticotropin receptor number and messenger RNA in cultured human adrenocortical cells by corticotropin and angiotensin II.
The regulation of ACTH receptor binding sites and mRNA by ACTH and angiotensin II (A-II) was studied using cultured human adrenal fasciculata reticularis cells (HAC). These cells expressed two major ACTH receptor transcripts of 1.8 and 3.4 kb and three minor ones of 4, 7, and 11 kb. ACTH increased the levels of all these transcripts in a time- and dose-depen
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9. Scavenger receptor class B, type I (SR-BI) is the major route for the delivery of high density lipoprotein cholesterol to the steroidogenic pathway in cultured mouse adrenocortical cells
The class B, type I scavenger receptor, SR-BI, binds high density lipoprotein (HDL) and mediates the selective uptake of HDL cholesteryl ester (CE) by cultured transfected cells. The high levels of SR-BI expression in steroidogenic cells in vivo and its regulation by tropic hormones provides support for the hypothesis that SR-BI is a physiologically rel
The National Academy of Sciences of the USA.
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10. Targeted disruption of the mouse gene encoding steroidogenic acute regulatory protein provides insights into congenital lipoid adrenal hyperplasia
An essential component of regulated steroidogenesis is the translocation of cholesterol from the cytoplasm to the inner mitochondrial membrane where the cholesterol side-chain cleavage enzyme carries out the first committed step in steroidogenesis. Recent studies showed that a 30-kDa mitochondrial phosphoprotein, designated steroidogenic acute regulatory pro
The National Academy of Sciences of the USA.
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11. Abnormal hormone responses of an adrenocortical cancer adenyl cyclase
Properties of adenyl cyclase of normal adrenals and of a corticosterone-producing adrenal cancer of the rat have been compared. Enzyme activity was found in all particulate fractions of both tissues. The cyclase of the tumor as well as of the adrenals was stimulated by adrenocorticotropic hormone (ACTH) over similar concentration ranges. Unexpectedly, the tu
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12. Lactation as a model for naturally reversible hypercorticalism plasticity in the mechanisms governing hypothalamo-pituitary- adrenocortical activity in rats.
Steady state levels of hypothalamic expression of the genes encoding corticotropin-releasing hormone (CRH), proopiomelanocortin (POMC), arginine vasopressin (AVP), and oxytocin (OT) were studied in rats to investigate the mechanisms underlying the transitions between hypercorticalism during lactation and normocorticalism upon weaning. During lactation, CRH m