Airway Remodeling
Mostrando 1-12 de 46 artigos, teses e dissertações.
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1. Estudo da ativação eosinofílica e de matriz extracelular de tecido pulmonar periférico em cobaias com inflamação alérgica pulmonar: efeitos do tratamento com dexametasona e antagonista do receptor do cisteinil-leucotrieno D4
Aims: Compare the effects of montelukast or dexamethasone treatments on eosinophilic recruitment, eotaxin, RANTES, fibronectin, IGF-I and NF-B positive cells of distal lung parenchyma and also in airway walls of guinea pigs (GP) with chronic allergic inflammation. Methods: GP were inhaled with ovalbumin (OVA group-2x/week/4weeks). After 4th inhalation, GP we
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 09/08/2012
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2. Short-term exposure of mice to cigarette smoke and/or residual oil fly ash produces proximal airspace enlargements and airway epithelium remodeling
Chronic obstructive pulmonary disease (COPD) is associated with inflammatory cell reactions, tissue destruction and lung remodeling. Many signaling pathways for these phenomena are still to be identified. We developed a mouse model of COPD to evaluate some pathophysiological mechanisms acting during the initial stage of the disease. Forty-seven 6- to 8-week-
Brazilian Journal of Medical and Biological Research. Publicado em: 2011-05
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3. Respiratory mechanics do not always mirror pulmonary histological changes in emphysema
OBJECTIVE: To verify the accordance of functional and morphometric parameters during the development of emphysema. METHODS: BALB/c mice received a nasal drop of either papain or saline solution and were studied after 1, 3, 15, 28, and 40 days. Functional parameters, such as airway resistance, tissue damping, and tissue elastance, were analyzed. To evaluate t
Clinics. Publicado em: 2011
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4. Inflammation and remodeling in infantile, juvenile and adult allergic sensitized mice / Inflamação e remodelamento pulmonar em camundongos com sensibilização alérgica em diferentes idades: um estudo comparativo
A prevalência mundial de asma na infância é alta. Alterações estruturais das vias aéreas são observadas na asma, e podem ocorrer precocemente na infância. Este estudo tem como objetivo comparar os resultados de um modelo de sensibilização alérgica, em camundongos de diferentes idades. Para tanto foram utilizados camundongos Balb/C pré-desmamados,
Publicado em: 2010
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5. Asthma: where is it going?
Asthma is characterized by reversible airway obstruction, airway hyperresponsiveness, and airway inflammation. Although our understanding of its pathophysiological mechanisms continues to evolve, the relative contributions of airway hyperresponsiveness and inflammation are still debated. The first mechanism identified as important for asthma was bronchial hy
Brazilian Journal of Medical and Biological Research. Publicado em: 20/08/2008
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6. Estudo da mecânica oscilatória e do remodelamento de tecido pulmonar periférico em modelo de inflamação alérgica em cobaias: efeitos da inibição da óxido nítrico sintase induzida / Oscillatory mechanics and periphery lung tissue remodeling study in an allergic inflammation model in guinea pigs: effects of inducible nitric oxide synthase inhibition
INTRODUCTION: The importance of lung parenchyma in functional asthma impairment has been recently addressed. Although the inducible nitric oxide synthase (iNOS) activation amplifies chronic inflammation-induced airway responsiveness and remodeling, its effect on lung parenchyma has not been previously investigated. OBJECTIVE: To evaluate the influence of iNO
Publicado em: 2008
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7. Protective effects of phosphodiesterase inhibitors on lung function and remodeling in a murine model of chronic asthma
The aim of the present study was to compare the efficacy of a novel phosphodiesterase 4 and 5 inhibitor, LASSBio596, with that of dexamethasone in a murine model of chronic asthma. Lung mechanics (airway resistance, viscoelastic pressure, and static elastance), histology, and airway and lung parenchyma remodeling (quantitative analysis of collagen and elasti
Brazilian Journal of Medical and Biological Research. Publicado em: 2006-02
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8. Role of matrix metalloproteinases in the development of airway inflammation and remodeling
Matrix metalloproteinases (MMPs) are a major group of proteases known to regulate extracellular matrix (ECM) turnover and so they have been suggested to be important in the process of lung disease associated with tissue remodeling. This has led to the concept that modulation of airway remodeling including excessive proteolysis damage to the tissue may be of
Brazilian Journal of Medical and Biological Research. Publicado em: 2005-10
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9. Role of Insulin-like Growth Factor Binding Protein-3 in Allergic Airway Remodeling
Rationale: The hallmarks of allergic asthma are airway inflammation, obstruction, and remodeling. Airway remodeling may lead to irreversible airflow obstruction with increased morbidity and mortality. Despite advances in the treatment of asthma, the mechanisms underlying airway remodeling are still poorly understood. We reported that insulin-like growth fact
American Thoracic Society.
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10. Environmental tobacco smoke exposure does not prevent corticosteroids reducing inflammation, remodeling, and airway hyperreactivity in mice exposed to allergen
The ability of corticosteroids to reduce airway inflammation and improve lung function is significantly reduced in asthmatics who are tobacco smokers compared with asthmatics who are nonsmokers. As not only high levels of tobacco smoke exposure in active smokers, but also significantly lower levels of tobacco smoke exposure from passive environmental tobacco
American Physiological Society.
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11. Early Growth Response-1 Suppresses Epidermal Growth Factor Receptor–Mediated Airway Hyperresponsiveness and Lung Remodeling in Mice
Transforming growth factor (TGF)-α and its receptor, the epidermal growth factor receptor, are induced after lung injury and are associated with remodeling in chronic pulmonary diseases, such as pulmonary fibrosis and asthma. Expression of TGF-α in the lungs of adult mice causes fibrosis, pleural thickening, and pulmonary hypertension, in addition to incre
American Thoracic Society.
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12. Adiponectin Deficiency Increases Allergic Airway Inflammation and Pulmonary Vascular Remodeling
Obesity is associated with an increased incidence and severity of asthma, as well as other lung disorders, such as pulmonary hypertension. Adiponectin (APN), an antiinflammatory adipocytokine, circulates at lower levels in the obese, which is thought to contribute to obesity-related inflammatory diseases. We sought to determine the effects of APN deficiency
American Thoracic Society.