Allograft Rejection
Mostrando 1-12 de 217 artigos, teses e dissertações.
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1. Structural Integrity and Cellular Viability of Cryopreserved Allograft Heart Valves in Right Ventricular Outflow Tract Reconstruction: Correlation of Histopathological Changes with Donor Characteristics and Preservation Times
Abstract Introduction: Cryopreserved allograft heart valves (CAHV) show longer event-free survival compared to other types of protheses. However, all patients develop early and/or late allograft failure. Negative predictors are clinical, and there is a lack of evidence whether they correspond with the microscopic structure of CAHV. We assessed histopatholog
Brazilian Journal of Cardiovascular Surgery. Publicado em: 2022
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2. Heart Transplantation for Chagas Cardiomyopathy
Abstract Heart transplantation (HT) is an established treatment for patients with advanced heart failure (HF). Chagas disease (CD), caused by the Trypanosoma cruzi (T.cruzi) is an important cause of HF in Latin America. Considering CD is a chronic infectious disease, the use of immunosuppressive therapy after HT can reactivate T. cruzi infection and compromi
Int. J. Cardiovasc. Sci.. Publicado em: 2020-12
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3. Renal transplant patients with preformed anti-HLA antibodies: early biopsy findings and clinical outcomes
Resumo Introdução: A fibrose renal é o desfecho de um processo iniciado no transplante, com reperfusão, isquemia e inflamação precoce, que progride ao longo do tempo com fenômenos imunológicos e não imunológicos. A identificação de marcadores morfológicos e a intervenção precoce poderiam melhorar a função e a sobrevida do enxerto. Objetivo
J. Bras. Nefrol.. Publicado em: 12/09/2019
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4. Impact of co-blocking the costimulatory signals on immune-related genes after high-risk rabbit corneal allograft using 2nd-generation DNA sequencing technology
Abstract The aim of this study was to evaluate the impact and mechanism of co-blocking of costimulatory signals CD28-B7-CD40-CD40L during immune allograft rejection. Forty-eight recipient rabbits were prepared as a high-risk corneal allograft model. After surgery, the animals were randomly divided into: control group, MR1 group, anti-B7 group, and co-blockin
Genet. Mol. Biol.. Publicado em: 18/07/2019
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5. Predicting urine output after kidney transplantation: development and internal validation of a nomogram for clinical use
ABSTRACT Purpose: To analyze pre-transplantation and early postoperative factors affecting post-transplantation urine output and develop a predictive nomogram. Patients and Methods: Retrospective analysis of non-preemptive first transplanted adult patients between 2001-2016. The outcomes were hourly diuresis in mL/Kg in the 1st (UO1) and 8th (UO8) postoper
Int. braz j urol.. Publicado em: 27/06/2019
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6. Non-invasive messenger RNA transcriptional evaluation in human kidney allograft dysfunction
The aim of the present study was to evaluate messenger RNA expression in kidney allograft recipients. Forty-four kidney transplant recipients were evaluated up to three months after grafting. After transplantation, peripheral blood samples were drawn sequentially for real-time polymerase chain reaction analyses of perforin and TIM-3 genes. Biopsies were obta
Braz J Med Biol Res. Publicado em: 17/05/2018
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7. Impact of specimen adequacy on the assessment of renal allograft biopsy specimens
The Banff classification was introduced to achieve uniformity in the assessment of renal allograft biopsies. The primary aim of this study was to evaluate the impact of specimen adequacy on the Banff classification. All renal allograft biopsies obtained between July 2010 and June 2012 for suspicion of acute rejection were included. Pre-biopsy clinical data o
Braz J Med Biol Res. Publicado em: 26/04/2016
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8. Issues in solid-organ transplantation in children: translational research from bench to bedside
In this review, we identify important challenges facing physicians responsible for renal and cardiac transplantation in children based on a review of the contemporary medical literature. Regarding pediatric renal transplantation, we discuss the challenge of antibody-mediated rejection, focusing on both acute and chronic antibody-mediated rejection. We review
Clinics. Publicado em: 2014-01
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9. New immunosuppressive agents in pediatric transplantation
Immunosuppressive therapy in pediatrics continues to evolve. Over the past decade, newer immunosuppressive agents have been introduced into adult and pediatric transplant patients with the goal of improving patient and allograft survival. Unfortunately, large-scale randomized clinical trials are not commonly performed in children. The purpose of this review
Clinics. Publicado em: 2014-01
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10. Long-term outcomes of children after solid organ transplantation
Solid organ transplantation has transformed the lives of many children and adults by providing treatment for patients with organ failure who would have otherwise succumbed to their disease. The first successful transplant in 1954 was a kidney transplant between identical twins, which circumvented the problem of rejection from MHC incompatibility. Further pro
Clinics. Publicado em: 2014-01
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11. In vitro proliferation and differentiation of hepatic oval cells and their potential capacity for intrahepatic transplantation
Hepatic oval cells (HOCs) are recognized as facultative liver progenitor cells that play a role in liver regeneration after acute liver injury. Here, we investigated the in vitro proliferation and differentiation characteristics of HOCs in order to explore their potential capacity for intrahepatic transplantation. Clusters or scattered HOCs were detected in
Braz J Med Biol Res. Publicado em: 30/07/2013
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12. Vias efetoras pelas quais a Hsp70 de Mycobacterium tuberculosis inibe a rejeição aguda em um modelo de aloenxerto cutâneo
Transplantation of solid organs has emerged as a viable therapeutic modality for the treatment of a variety of disorders. Rejection of solid organ allografts is the result of a complex range of interactions involving coordination between both the innate and adaptive immune system. Therewith, a major goal of clinical organ transplantation is to induce a donor
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 26/03/2012