Allylation
Mostrando 1-12 de 13 artigos, teses e dissertações.
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1. Synthesis and Cytotoxic Evaluation of 1H-1,2,3-Triazol-1-ylmethyl-2,3-dihydronaphtho[1,2-b]furan-4,5-diones
ABSTRACT The 1,2-naphthoquinone compound was previously considered active against solid tumors. Moreover, glycosidase inhibitors such as 1,2,3-1H triazoles has been pointed out as efficient compounds in anticancer activity studies. Thus, a series of eleven 1,2-naphthoquinones tethered in C2 to 1,2,3-1H-triazoles 9a-k were designed, synthesized and their cyto
An. Acad. Bras. Ciênc.. Publicado em: 15/02/2018
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2. Synthesis of Chiral 1,3-Dienes through Ring-Closing Metathesis of Enantioenriched Enynes: Potential Precursors of Morphane Analogs
ABSTRACT A simple methodology for the synthesis of enynes by indium mediated diastereoselective allylation of aromatic N-tert-butanesulfinylimines bearing alkenyl groups at ortho-position with allyl bromide has been developed. The addition of the allyl indium intermediate to the chiral imine took place with excellent diastereoselectivity. Ruthenium-catalyzed
An. Acad. Bras. Ciênc.. Publicado em: 2018
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3. APLICAÇÃO DE AMIDOXIMAS COMO CATALISADORES DA REAÇÃO DE ALILAÇÃO POR ALILTRIFLUOROBORATO DE POTÁSSIO EM MEIO BIFÁSICO
We describe the application of an amidoxime as catalyst in the synthesis of homoallylic alcohols from the allylation reaction of aldehydes with different features using potassium allyltrifluoroborate. The reaction was conducted with a catalytic amount of the appropriate amidoxime in a biphasic system (water:dichloromethane), open atmosphere and ambient tempe
Quím. Nova. Publicado em: 2016-12
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4. Sintese e atividade biologica de analogos furanicos da goniotalamina / Synthesis and biological activity of furan analogues of goniothalamin
This work describes the preparation of furan analogues of goniothalamin (compounds 31, 32 and 33) in both enantiomeric forms through the utilization of Keck asymmetric allylation and ring-closing methatesis reaction. These analogues were prepared in good overall yield and excellent enantiomeric ratio. These novel compounds were evaluated as antiproliferative
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 07/07/2009
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5. Estudos visando a elucidação estrutural de uma diidro-2H-piranona natural / Studies toward the structural elucidation of a natural diidro-2H-piranone
Esta dissertação de mestrado trata da síntese da Criptomoscatona D2, uma lactona isolada pelo grupo de pesquisa dos Profs. Cavalheiro e Yoshida a partir da Cryptocarya moschata, planta encontrada em território brasileiro, cujas configurações relativa e absoluta ainda não foram determinadas. Além de auxiliar em sua elucidação estrutural a síntese d
Publicado em: 2007
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6. ReaÃÃo de alilaÃÃo do tipo Barbier de benzaldeidos substituÃdos mediada por estanho em meio aquoso
O estudo de reaÃÃes organometÃlicas ganhou novo impulso, a partir da dÃcada de 1980, com a descoberta de que algumas dessas reaÃÃes mediadas por metais poderiam ser realizadas na presenÃa de Ãgua. A partir de entÃo, a reaÃÃo de Barbier tem sido uma das mais estudadas com diversos metais, destacando-se o, Ãndio, zinco e estanho. Neste trabalho, a
Publicado em: 2007
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7. Alilação e crotilação catalítica e enantiosseletiva de aldeídos
The field of chiral catalysis has experienced explosive growth over the last two decades. By now, many of the classical reactions in organic synthesis can be carried out efficiently in asymmetric manner. As one of the fundamental and powerful C-C bond-forming reactions, enantioselective catalytic allylation (ECA) and crotylation (ECC) of aldehydes has attrac
Química Nova. Publicado em: 2006-10
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8. Goniotalamina, epoxigoniotalamina, argentilactona e derivados : sinteses totais e atividades antiproliferativas contra celulas tumorais humanas / Goniothalamin, goniothalamin oxide and argentilactone: total syntheses and antiproliferative activies against cells of human cancer
Natural goniothalamin (24), goniothalamin oxide (25) and argentilactone (23) are 5,6-di-hydro-2H-pyran-2-one that display many interesting biological activities. The total syntheses of these natural products as well as some of their derivatives are described. Goniothalamin (24) was synthesized via catalytic asymmetric allylation of a-benzyloxyacetaldehyde (3
Publicado em: 2005
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9. Studies of stereocontrolled allylation reactions for the total synthesis of phorboxazole A
A highly convergent total synthesis of the potent anticancer agent (+)-phorboxazole A (1) is accomplished. Four components (3–6) are assembled with considerations for control of absolute and relative stereochemistry. Iterative asymmetric allylation methodology addresses key stereochemical features in the preparation of the 2,6-cis- and 2,6-trans-tetrahydro
National Academy of Sciences.
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10. New synthetic routes to synthons suitable for 2'-O-allyloligoribonucleotide assembly.
New synthetic routes have been devised for the high yield preparation of protected 2'-O-allylribonucleoside-3'-O-phosphoramidites, exemplified by the ribonucleosides guanosine and 2,6-diaminopurine riboside (2-aminoadenosine). Key features are the use of versatile intermediates and an easy allylation step. The development of a novel synthon based on 2'-O-all
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11. Tolerance for mutations and chemical modifications in a siRNA
Short interfering RNA (siRNA), the active agent of RNA interference, shows promise of becoming a valuable tool in both basic and clinical research. We explore the tolerance to mutations and chemical modifications in various parts of the two 21-nt strands of a siRNA targeting the blood clotting initiator Tissue Factor. The mutations were G/C transversions. Th
Oxford University Press.
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12. Synthesis of 2'-modified nucleotides and their incorporation into hammerhead ribozymes.
Several 2'-modified ribonucleoside phosphoramidites have been prepared for structure-activity studies of the hammerhead ribozyme. The aim of these studies was to design and synthesize catalytically active and nuclease-resistant ribozymes. Synthetic schemes for stereoselective synthesis of the R isomer of 2'-deoxy-2'-C-allyl uridine and cytidine phosphoramidi