Alzheimer Disease Diagnosis
Mostrando 1-12 de 98 artigos, teses e dissertações.
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1. Decision tree-based classification as a support to diagnosis in the Alzheimer’s disease continuum using cerebrospinal fluid biomarkers: insights from automated analysis
Objective: Cerebrospinal fluid (CSF) biomarkers add accuracy to the diagnostic workup of cognitive impairment by illustrating Alzheimer’s disease (AD) pathology. However, there are no universally accepted cutoff values for the interpretation of AD biomarkers. The aim of this study is to determine the viability of a decision-tree method to analyse CSF bioma
Brazilian Journal of Psychiatry. Publicado em: 2022
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2. Evaluation of 10-minute post-injection 11C-PiB PET and its correlation with 18F-FDG PET in older adults who are cognitively healthy, mildly impaired, or with probable Alzheimer’s disease
Objective: Positron emission tomography (PET) allows in vivo evaluation of molecular targets in neurodegenerative diseases, such as Alzheimer’s disease. Mild cognitive impairment is an intermediate stage between normal cognition and Alzheimer-type dementia. In vivo fibrillar amyloid-beta can be detected in PET using [11C]-labeled Pittsburgh compound B (11C
Brazilian Journal of Psychiatry. Publicado em: 2022
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3. 12-item version of Boston Naming Test: usefulness in the diagnosis of primary progressive aphasia, frontotemporal dementia, and Alzheimer's disease
RESUMO. A versão de 12 itens do Teste de Nomeação de Boston (TNB) foi adaptada para a Argentina para a detecção de demência por doença de Alzheimer (DA), com escores semelhantes à versão original de 60 itens (sensibilidade e especificidade de 85 e 94%, respectivamente) sem influência demográfica (idade e escolaridade). Até o momento, não foram r
Dementia & Neuropsychologia. Publicado em: 2022
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4. Early diagnosis and treatment of Alzheimer’s disease: new definitions and challenges
The prevalence of Alzheimer’s disease (AD), a progressive neurodegenerative disorder, is expected to more than double by 2050. Studies on the pathophysiology of AD have been changing our understanding of this disorder and setting a new scenario for drug development and other therapies. Concepts like the “amyloid cascade” and the “continuum of AD,”
Braz. J. Psychiatry. Publicado em: 2020-08
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5. A cerebrospinal fluid biosignature for the diagnosis of Alzheimer’s disease
Braz. J. Psychiatry. Publicado em: 09/12/2019
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6. Prevalence of dementia in patients seen at a private hospital in the Southern Region of Brazil
RESUMO Objetivo Avaliar o perfil epidemiológico dos pacientes atendidos em um ambulatório de demência. Métodos Estudo retrospectivo realizado pela revisão de prontuários com busca de dados sobre sexo, raça, idade, escolaridade e diagnóstico de pacientes atendidos de 2008 a 2015. Resultados Foram estudados 760 pacientes, com predomínio do sexo fem
Einstein (São Paulo). Publicado em: 24/10/2019
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7. Behavioral variant of frontotemporal dementia or frontal variant of Alzheimer's disease? A case study
RESUMO A doença de Alzheimer (DA) tem apresentações clínicas heterogêneas. Amnésia progressiva associada a demência é a forma mais comum, mas apresentações não-amnésticas são também reconhecidas. Relatamos um caso de variante frontal da DA. Um mulher destra, de 68 anos, consultou-se devido a transtornos comportamentais progressivos, com altera�
Dement. neuropsychol.. Publicado em: 23/09/2019
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8. Subjective cognitive impairment, cognitive disorders and self-perceived health: The importance of the informant
RESUMO Há grande divergência de resultados na literatura em relação à relevância clínica e à etiologia do comprometimento cognitivo subjetivo (CCS). Atualmente, o CCS é estudado como um sintoma pré-clínico da doença de Alzheimer, antes de se estabelecer um possível diagnóstico de CCL. A hipótese é que o CCS pode estar associado a um desempenh
Dement. neuropsychol.. Publicado em: 23/09/2019
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9. Posturographic analysis of older adults without dementia and patients with Alzheimer’s disease: A cross-sectional study
RESUMO. Ferramentas clínicas adicionais devem ser investigadas para facilitar e auxiliar o diagnóstico prévio do declínio cognitivo. O controle postural piora com o envelhecimento e este fato pode estar relacionado com o comprometimento cognitivo patológico. Objetivo: comparar o equilíbrio de adultos idosos sem demência no grupo controle (GC) e com d
Dement. neuropsychol.. Publicado em: 18/06/2019
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10. The validity and reliability of the CAMDEX-DS for assessing dementia in adults with Down syndrome in Brazil
Objective: Alzheimer’s disease occurs at a higher prevalence and an earlier age in individuals with Down syndrome (DS) than typically developing individuals. However, diagnosing dementia in individuals with intellectual disability remains a challenge due to pre-existing cognitive deficits. The aim of this study was to investigate the validity and reliabil
Braz. J. Psychiatry.. Publicado em: 22/10/2018
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11. Support vector machine-based classification of neuroimages in Alzheimer’s disease: direct comparison of FDG-PET, rCBF-SPECT and MRI data acquired from the same individuals
Objective: To conduct the first support vector machine (SVM)-based study comparing the diagnostic accuracy of T1-weighted magnetic resonance imaging (T1-MRI), F-fluorodeoxyglucose-positron emission tomography (FDG-PET) and regional cerebral blood flow single-photon emission computed tomography (rCBF-SPECT) in Alzheimer’s disease (AD). Method: Brain T1-MR
Rev. Bras. Psiquiatr.. Publicado em: 02/10/2017
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12. Association study in Alzheimer’s disease of single nucleotide polymorphisms implicated with coffee consumption
Background There is evidence from animal and in vitro models of the protective effects of caffeine in Alzheimer’s disease. The suggested mechanisms through which caffeine may protect neurons against Alzheimer’s disease pathology include the facilitation of beta-amyloid clearance, upregulation of cholinergic transmission, and increased neuronal plasticit
Arch. Clin. Psychiatry (São Paulo). Publicado em: 2015-06