Alzheimer Disease Genetics
Mostrando 1-12 de 16 artigos, teses e dissertações.
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1. Evaluation of DNA polymorphisms in candidate genes of mild cognitive impairment and Alzheimers disease Patients / Avaliação de polimorfismos de DNA em genes candidatos de pacientes com comprometimento cognitivo leve e doença de Alzheimer
Alzheimers disease (AD) is complex, and its ethiology is not completely understood yet. It is likely that multifactorial components do account for this pathology development, being the allelic variant APOE*E4 is the only well-established genetic risk factor so far. Recently, a series of polymorphisms located at different genes were related to AD, suggesting
Publicado em: 2010
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2. AnÃlise in silico de novos potenciais polimorfismos genÃticos de risco na DoenÃa de Alzheimer em bancos de dados de Microarrays
Genomic and Proteomic studies of neurodegenerative disorders require complementary approaches to integrate the massive amount of data generated in high throughput experimental procedures. We propose a Bioinformatics pipeline in which expression studies guide the selection of candidate genes that should be screened for potential new genetic variations from a
Publicado em: 2009
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3. Polymorphisms of the APOE and LRP and Alzheimer s disease in Brazilian individuals / "Polimorfismos da região promotora e codificadora do gene APOE e do gene LRP na doença de Alzheimer em indivíduos brasileiros"
Objetivos: Analisar a relevância dos polimorfismos da APOE, -491 e -219 e do LRP na ocorrência de doença de Alzheimer (DA) em indivíduos brasileiros. Metodologia: Realizou-se o estudo em 120 pacientes com DA provável e em 120 controles. Resultados: Houve diferença quanto à freqüência do alelo e4 da APOE, (31% dos pacientes e 10% dos controles). A pr
Publicado em: 2003
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4. BOOK REVIEWS: Familial Alzheimer's Disease. Molecular Genetics and Clinical Perspectives. (Neurological Disease and Therapy Series/2).
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5. Genetics and Alzheimer's Disease
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6. Familial Alzheimer's Disease. Molecular Genetics and Clinical Perspectives
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7. Medical genetics: advances in brief: Specificity, sensitivity, and predictive value of apolipoprotein-E genotyping for sporadic Alzheimer's disease.
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8. The Amyloid Precursor Protein Locus and Very-Late-Onset Alzheimer Disease
Although mutations in the amyloid-β precursor protein (APP) gene are known to confer high risk of Alzheimer disease (AD) to a small percentage of families in which it has early onset, convincing evidence of a major role for the APP locus in late-onset AD has not been forthcoming. In this report, we have used a covariate-based affected-sib-pair linkage metho
The American Society of Human Genetics.
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9. Genetic dissection of Alzheimer disease, a heterogeneous disorder.
The genetics of Alzheimer disease (AD) are complex and not completely understood. Mutations in the amyloid precursor protein gene (APP) can cause early-onset autosomal dominant AD. In vitro studies indicate that cells expressing mutant APPs overproduce pathogenic forms of the A beta peptide, the major component of AD amyloid. However, mutations in the APP ge
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10. Association of late-onset Alzheimer's disease with genetic variation in multiple members of the GAPD gene family
Although several genes have been implicated in the development of the early-onset autosomal dominant form of Alzheimer's disease (AD), the genetics of late-onset AD (LOAD) is complex. Loci on several chromosomes have been linked to the disease, but so far only the apolipoprotein E gene has been consistently shown to be a risk factor. We have performed a larg
National Academy of Sciences.
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11. Molecular triangulation: Bridging linkage and molecular-network information for identifying candidate genes in Alzheimer's disease
A major challenge in human genetics is identifying the molecular basis of common heritable disorders. In contrast to rare single-gene diseases, multifactorial disorders are thought to arise from the combined effect of multiple gene variants, such that any single variant may have only a modest effect on disease susceptibility. We present a method to identify
National Academy of Sciences.
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12. A Second Locus for Very-Late-Onset Alzheimer Disease: A Genome Scan Reveals Linkage to 20p and Epistasis between 20p and the Amyloid Precursor Protein Region
We used a covariate-based linkage method to reanalyze genome scan data from affected sibships collected by the Alzheimer Disease (AD) Genetics Initiative of the National Institute of Mental Health. As reported in an earlier article, the amyloid-β precursor protein (APP) region is strongly linked to affected sib pairs of the oldest current age (i.e., age eit
The American Society of Human Genetics.