Aminoalcohols
Mostrando 1-12 de 15 artigos, teses e dissertações.
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1. Chiral Amino and Imino-Alcohols Based on (R)-Limonene
Derivatives of the natural occurring and inexpensive terpene (R) -limonene were synthetized and completely characterized. Starting from internal olefin epoxidation, followed by epoxide opening with sodium azide and azide reduction with LiAlH4, two chiral amino-alcohols were obtained. The amino-alcohols were reacted with three different aldehydes, generating
J. Braz. Chem. Soc.. Publicado em: 2020-03
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2. A straightforward and efficient method for the synthesis of diversely substituted β-aminoketones and γ-aminoalcohols from 3-(N,N-dimethylamino)propiophenones as starting materials
Bibliotecas de novos β-aminocetonas e γ-aminoálcoois que mostram uma grande diversidade estrutural foram facilmente obtidas a partir de uma abordagem simple, utilizando os derivados da 3-(N,N-dimetilamino)propiofenona como material de partida chave. O procedimento envolveu inicialmente a N-alquilação de benzilaminas secundárias com derivados de propiof
J. Braz. Chem. Soc.. Publicado em: 2013-09
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3. Hyphenating the curtius rearrangement with Morita-Baylis-Hillman adducts: synthesis of biologically active acyloins and vicinal aminoalcohols
Um rearranjo de Curtius, utilizando adutos de Morita-Baylis-Hillman como substrato, foi realizado em uma sequência que permitiu a síntese de várias hidroxi-cetonas (aciloínas) com uma grande diversidade estrutural e com bons rendimentos globais. Por sua vez, essas aciloínas foram transformadas em 1,2-amino-alcoóis de configuração relativa anti, atrav
Journal of the Brazilian Chemical Society. Publicado em: 2011-08
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4. Reação de Morita-Baylis-Hillman em quimica organica. 1-Estudos mecanisticos por espectrometria de massas. 2-Sintese de farmacos, sintese diastereosseletiva de 1,2-amino-alcoois via rearranjo de Curtius / The Morita-Baylis-Hillman reaction in organic chemistry. 1-Mechanistic studies by mass spectrometry. 2-Synthesis of drugs, diastereoselective synthesis of 1,2-aminoalcohols via Curtis rearrangement
Esse trabalho de doutorado visou explorar a reação de Morita-Baylis- Hillman (MBH) nos aspectos relacionados ao seu mecanismo e a utilização de seus adutos, como substratos para síntese de moléculas com propriedades biológicas. Realizamos estudos mecanísticos dessa reação, utilizando ESI-MS, sendo possível, interceptar e caracterizar, em fase gaso
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 21/08/2009
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5. Síntese de aminoálcoois derivados do D-manitol
Aminoalcohols have found important applications in synthetic and medicinal chemistry, being used as chiral building blocks for the synthesis of many biologically active compounds. This class of compounds has been also used as chiral auxiliaries and ligands in asymmetric synthesis. Due to the importance of aminoalcohols in the treatment of several diseases, s
Química Nova. Publicado em: 2008
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6. SÍNTESE, CARACTERIZAÇÃO E AVALIAÇÃO DA ATIVIDADE IMUNOSSUPRESSORA DE DIAMINAS E AMINOÁLCOOIS LIPOFÍLICOS
Immunosuppressant drugs are the main drugs that can affect the immune response, reducing the activation of the innate and acquired immunities. The immunosuppresive drugs are used in the treatment of several autoimmune diseases, some allergies, and in the prevention and/or treatment of the rejection of transplanted organs and tissues. The objective of the pre
Publicado em: 2008
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7. Ligantes quirais nitrogenados em reações de hidrogenação catalitica assimetrica e redução enantiosseletiva com oxazaborolidinas / Nitrogen chiral ligants in asymmetric hydrogenation and enantioselective reduction using oxazaborolidine
O presente trabalho tem como objetivo a síntese e aplicação de novos aminoálcoois e ligantes quirais fosforados derivados desses e sua aplicação em catálise assimétrica. Com este intuito, foram sintetizados os aminoálcoois (2R)-2-[(2R) azolan-2-il]-2-feniletan-1-ol (4) e (2R)-2-[(2R) hexaidro-2-piridinil]-2-feniletan-1-ol (6) que são inéditos na l
Publicado em: 2005
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8. Sintese enantiosseletiva de efedrina
In this work, some methodologies for enantioselective reduction of the prochiral diketone 1-phenyl-1,2-propanedione (3) mediated by Baker´s Yeast (Saccharomyces cerevisiae) had been studied. This diketone was synthesized by a-oxymation of propiophenone (7) (68-80%), followed by acidic hydrolysis of (2E)-1-phenyl-1,2-propanodione 2-oxime (8) (62-77%). The gr
Publicado em: 2003
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9. Citocidade de derivados de beta -enaminocetonas em celulas de mamiferos
Studies on structure-activity relationships are essential for the development of new pharmacological drugs. In this work we have investigated the cytotoxicity of new structurally related synthetic compounds, the y-aminoalcohols 2-pentanol-4 benzylamine (PBA), 2-pentanol-4-phenylamine (PPA) and the corresponding tetrahydro-I,3-oxazines, 2-pentanol-4benzyloxaz
Publicado em: 1997
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10. Adição de silil-enoleteres a aldiminas aromaticas ativadas : sintese, C-metilação e redução estereosseletiva do B-aminocetonas secundarias N-aril-substituidas
A novel entry into secondary N-Aryl-b-aminoketones (109-123) is described which features the addition of silyleno- lethers to aromatic aldimines activated by trimethylsilyl trifIuoromethanesulphonate (TMSOTf). Good yields (33-98%) achieved whith catalitic TMSOTf (15 mol%), while only BF3:OEt2 and TeCI4 yielded b-aminoketones among the Lewis acid employed (Ti
Publicado em: 1989
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11. In Vitro Activity of Lumefantrine (Benflumetol) against Clinical Isolates of Plasmodium falciparum in Yaoundé, Cameroon
The in vitro antimalarial activity of the new Chinese synthetic drug, lumefantrine, also known as benflumetol (a fluorene derivative belonging to the aminoalcohol class), was determined by an isotopic microtest against 61 fresh clinical isolates of Plasmodium falciparum and compared with that of other established antimalarial agents. The geometric mean 50% i
American Society for Microbiology.
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12. Choline-containing bacteriophage receptors in Streptococcus pneumoniae.
Choline-containing teichoic acid seems to be essential for the adsorption of bacteriophage Dp-1 to pneumococci. This conclusion is based on the following observations: In contrast to pneumococci grown in choline-containing medium, cells grown in medium containing ethanolamine or other submethylated aminoalcohols instead of choline were found to be resistant