Anastrozole
Mostrando 1-10 de 10 artigos, teses e dissertações.
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1. The use of aromatase inhibitors in boys with short stature: what to know before prescribing?
ABSTRACT Aromatase is a cytochrome P450 enzyme (CYP19A1 isoform) able to catalyze the conversion of androgens to estrogens. The aromatase gene mutations highlighted the action of estrogen as one of the main regulators of bone maturation and closure of bone plate. The use of aromatase inhibitors (AI) in boys with short stature has showed its capability to imp
Arch. Endocrinol. Metab.. Publicado em: 2017-08
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2. Efeitos do anastrozol na periodontite induzida por ligadura em ratas ovariectomizadas / Effects of anastrozole on ligature-induced periodontitis in ovariectomized rats.
A deficiÃncia de estrÃgeno tem mostrado aumentar a remodelaÃÃo Ãssea, podendo afetar algumas doenÃas Ãsseas como a periodontite. A biossÃntese desse hormÃnio à catalisada pela enzima aromatase e sua inibiÃÃo à importante para terapia do cÃncer de mama. Os pacientes que usam inibidores da aromatase como o Anastrozol (ANA) mostram maior nÃmero d
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 16/02/2012
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3. Estudo do biomarcador p16 no carcinoma de mama de mulheres submetidas à endocrinoterapia primária de curta duração com tamoxifeno e anastrozol. / Expression of p16 in short term exposition with tamoxifen and anastrozole in postmenopausal women with breast invasive cancer.
Introdução: A endocrinoterapia é uma das principais responsáveis pela redução de mortalidade do câncer de mama. Biomarcadores preditivos de resposta celular precoce vêm sendo estudados com intuito de prever precocemente a hormonioresistência. Freqüentes deleções e mutações têm sido descritas no gene p16 em diversos tipos de tumores, mas pouco
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 25/11/2009
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4. Isolation and characterization of process related impurities in anastrozole active pharmaceutical ingredient
Três impurezas no intervalo de 0,08%-0,12% por área de pico foram detectadas no ingrediente farmacêutico ativo, anastrazol, por cromatografia líquida de alta eficiência (CLAE) em fase-reversa isocrática. Essas impurezas foram isoladas por prep-CLAE e caracterizadas por CL-EM/EM, CG/EM e dados experimentais de RMN. Com base nos resultados obtidos a part
Journal of the Brazilian Chemical Society. Publicado em: 2008
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5. Avaliação citológica em base líquida de fármacos moduladores estrogênicos
Hormone therapy is an important tool in the treatment of breast cancer and tamoxifen represents one of the most important drugs used in this type of treatment. Recently other drugs based on the inhibition of aromatase had been developed, this enzyme is responsible for the synthesis of estrogenic esteroids from the androgenic ones. The objective of this study
Publicado em: 2006
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6. Quantificação de farmacos em estudos de biodisponibilidade relativa por espectrometria de massas com a utilização da tecnica de fotoionização / Drug quantification for relative biovailability studies by means of photoionization mass spectrometry
The development of atmospheric pressure ionization techniques has been of utmost importance to turn high performance liquid chromatography coupled to mass spectrometry into a routine solution, enabling the development of robust, high performance, high sensitivity and specific quantitative methods. In this sense, the recent development of the atmospheric pres
Publicado em: 2006
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7. Formulation of anastrozole microparticles as biodegradable anticancer drug carriers
The purpose of this study was to develop poly(d,1-lactic-coglycolic acid) (PLGA)-based anastrozole microparticles for treatment of breast cancer. An emulsion/extraction method was used to prepare anastrozole sustained-release PLGA-based biodegradable microspheres. Gas chromatography with mass spectroscopy detection was used for the quantitation of the drug t
Springer-Verlag.
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8. Testosterone attenuates expression of vascular cell adhesion molecule-1 by conversion to estradiol by aromatase in endothelial cells: Implications in atherosclerosis
We previously reported that testosterone attenuated atherogenesis in LDLR−/− male mice, and that this effect of testosterone was most likely caused by its conversion to estradiol. Estradiol inhibits vascular cell adhesion molecule-1 (VCAM-1) expression, and expression of VCAM-1 is one of the early events in atherogenesis. We assessed the cellular mechani
The National Academy of Sciences.
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9. A new day dawns: women without oestrogen or is a balance best?
Building on the 30-year success story with tamoxifen, the question now is whether one agent can be used for treatment and prevention or should new medicines be targeted to specific applications? The early results with anastrozole suggest it could replace tamoxifen for treatment and should be tested as a preventive. Unfortunately, long-term testing of aromata
BioMed Central.
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10. Has tamoxifen had its day?
Tamoxifen is probably the most important drug in the history of the management of breast cancer and its development is a tribute to cross talk between laboratory scientists and clinical investigators. Its use as adjuvant therapy has led to a decrease of 20–30% in age-adjusted cause-specific mortality in the developed world and it is approved in the USA for
BioMed Central.