Anatoxin
Mostrando 1-12 de 12 artigos, teses e dissertações.
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1. Effects of a cyanobacterial extract containing-anatoxin-a(s) on the cardiac rhythm of Leurolestes circunvagans
This work presents the effects of an anatoxin-a(s)-containing extract on a cockroach semi-isolated heart preparation and the results supporting the extract’s biological activity on acetylcholinesterase (purified from ell). The presence of the toxin in cyanobacterial strains Anabaena spiroides (ITEP-024, ITEP-025 and ITEP-026) isolated from the Tapacurá re
Revista Brasileira de Farmacognosia. Publicado em: 29/05/2012
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2. Synthesis and strategic aplications of some neurotoxins produce for cyanobacteria / Síntese e aplicações estratégicas de algumas neurotoxinas produzidas por cianobactérias
As cianobactérias apresentam distribuição variada e podem ocorrer desde as regiões frias do ártico até os trópicos, em corpos dágua doce e no ambiente marinho. Algumas espécies de cianobactérias produzem compostos com conhecida toxidade, podendo causar efeitos deletérios em seres humanos e animais. Entre estes compostos estão os com atividade neu
Publicado em: 2009
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3. Determination of low tetanus or diphtheria antitoxin titers in sera by a toxin neutralization assay and a modified toxin-binding inhibition test
A method for the screening of tetanus and diphtheria antibodies in serum using anatoxin (inactivated toxin) instead of toxin was developed as an alternative to the in vivo toxin neutralization assay based on the toxin-binding inhibition test (TOBI test). In this study, the serum titers (values between 1.0 and 19.5 IU) measured by a modified TOBI test (Modi-T
Brazilian Journal of Medical and Biological Research. Publicado em: 2007-01
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4. Desenvolvimento de métodos analíticos por cromatografia gasosa acoplada à espectrometria de massas para a identificação e quantificação de anatoxina-A em amostras de água e florações algais / Development of analytical methods by gas chromatography/mass spectrometry for anatoxin-a identification and quantification in water and algae bloom samples
A poluição dos corpos dágua é de grande preocupação mundial, pois a maioria da população utiliza a água doce de reservatórios, represas ou rios como principal fonte de água potável. A presença no Brasil de florações de cianobactérias capazes de produzir anatoxina-a, revela a necessidade de métodos simples e rápidos que permitam sua detecç�
Publicado em: 2007
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5. Mecanismos moleculares da neutralização da atividade letal das toxinas escorpiônicas por anticorpos monoclonais e policlonais
The major goal of this thesis is the immunochemical study of the scorpion toxins. Four manuscripts were presented concerning this subject. In the first report, a detoxified immunogen was prepared by conjugation of a toxic fraction (TstFG50), of the T. serrulatus venom, with bovine serum alburnin (BSA). The immunogen was inject in mice for inducing antibodies
Publicado em: 2007
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6. Aspectos toxicológicos e químicos da Anatoxina-a e seus análogos
Anatoxin-a and its analogues are azabicyclic alkaloids that represent one of the most powerful nicotinic agonists known for the nicotinic acetylcholine receptor (nAChR). Because of this potent mechanism of action, anatoxin-a and its derivatives represent a target for the discovery of novel drugs. Their syntheses are useful for environmental monitoring and al
Química Nova. Publicado em: 2006-12
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7. Investigações preliminares sobre as alterações sexo-dependentes da glicemia produzidas por canatoxina em ratos
1. The chronical administration of canatoxin (0.1mg/kg of ac:tive protein) to intac:t maIe and femaIe rats induced a pronounced sex-reIated dependent aIteration upon the bIood glucose Ievels of the animaIs. Thus, whiIe the males exhibited hypergIycemia the femaIes showed hypoglycemia. 2. A rise in the circuIating glucose IeveIs comparable to that seen in maI
Publicado em: 1989
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8. Anatoxin-a interactions with cholinergic synaptic molecules.
Anatoxin-a, a bicyclic amine isolated from blue-green alga, binds to the nicotinic acetylcholine receptor of Torpedo electric tissue, thereby inducing conformational changes in the postsynaptic receptor--ion channel complex as evidenced by alterations in the binding of radiolabeled ligands to the complex. Anatoxin-a binds to the acetylcholine recognition sit
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9. Detection of Anatoxin-a(s) in Environmental Samples of Cyanobacteria by Using a Biosensor with Engineered Acetylcholinesterases
Bioassays are little used to detect individual toxins in the environment because, compared to analytical methods, these assays are still limited by several problems, such as the sensitivity and specificity of detection. We tentatively solved these two drawbacks for detection of anatoxin-a(s) by engineering an acetylcholinesterase to increase its sensitivity
American Society for Microbiology.
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10. DIPHTHERIA IMMUNIZATION WITH DIPHTHERIA TOXOID (ANATOXIN-RAMON)
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11. Geographical Segregation of the Neurotoxin-Producing Cyanobacterium Anabaena circinalis
Blooms of the cyanobacterium Anabaena circinalis are a major worldwide problem due to their production of a range of toxins, in particular the neurotoxins anatoxin-a and paralytic shellfish poisons (PSPs). Although there is a worldwide distribution of A. circinalis, there is a geographical segregation of neurotoxin production. American and European isolates
American Society for Microbiology.
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12. Hemagglutination method for detection of freshwater cyanobacteria (blue-green algae) toxins.
Strains of the freshwater cyanobacteria (blue-green algae) Anabaena flosaquae and Microcystis aeruginosa produced toxins that caused intermittent but repeated cases of livestock, waterfowl, and other animal deaths. They also caused illness, especially gastrointestinal, in humans. The most common group of toxins produced by these two species were peptide toxi