Androgens Deficiency
Mostrando 1-11 de 11 artigos, teses e dissertações.
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1. Classic and current concepts in adrenal steroidogenesis: a reappraisal
ABSTRACT Adrenal steroid biosynthesis and its related pathology are constant evolving disciplines. In this paper, we review classic and current concepts of adrenal steroidogenesis, plus control mechanisms of steroid pathways, distribution of unique enzymes and cofactors, and major steroid families. We highlight the presence of a “mineralocorticoid (MC) pat
Archives of Endocrinology and Metabolism. Publicado em: 2022
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2. Effects of male sex hormone on the plasma lipoprotein metabolism and CETP expression in sedentary and trained genetically modified mice / Efeitos de hormonios sexuais masculinos sobre o metabolismo das lipoproteinas plasmaticas e expressão da CETP em camundongos geneticamente modificados sedentarios e exercitados
Gender differences in lipoprotein profile and atherosclerotic disease risk are generally attributed to an attenuating effect of estrogen and/or to a proatherogenic action of androgens. In this work we studied the effects of dificiency and excess of testosterone on the lipoprotein metabolism and development of atherosclerosis in transgenic mice expressing CET
Publicado em: 2005
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3. "Análise da deficiência androgênica e terapia de reposição em homens idosos" / Analysis of the androgenic deficiency and replacement therapy in elderdy men
A deficiência androgênica acomete um percentual de homens idosos ainda não bem definido na literatura. São usados parâmetros séricos hormonais de homens jovens, e apesar disto, a terapia de reposição da testosterona vem sendo defendida e utilizada largamente por muitos autores. Várias vias de reposição são usadas tentando simular o ciclo fisioló
Publicado em: 2004
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4. Hiperplasia congenita das supra-renais por deficiencia classica da 21-hidroxilase : estudo transversal dos fatores envolvidos na densidade mineral ossea areal em 45 casos
INTRODUCTION: Glucocorticoids are essential in the treatment of patients with Congenital Adrenal Hyperplasia (CAH). The opposite actions of glucocorticoids and androgens in bone mass achievement justifies a study of bone mineral density (BMD) inpatients with CAH due to c1assic21-hydroxylase deficiency (CYP21A2). OBJECTIVES: To evaluate BMD in patients with C
Publicado em: 2001
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5. Avaliação funcional das celulas de Leydig e de Sertoli em 24 casos de ambiguidade genital com cariotipo 46,XY
The investigation of the origin of sex ambiguity is a very complex matter. Sex differentiation is dependent upon the action of two testicular hormones: testosterone and anti-Müllerian hormone (AMH). Although testicular function has traditionally been assessed only by examining the steroidogenic capacity of Leydig cells and spermatogenesis, it has recently b
Publicado em: 1999
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6. Regulation of interleukin-6, osteoclastogenesis, and bone mass by androgens. The role of the androgen receptor.
Interleukin-6 is an essential mediator of the bone loss caused by loss of estrogens. Because loss of androgens also causes bone loss, we have examined whether the IL-6 gene is regulated by androgens, and whether IL-6 plays a role in the bone loss caused by androgen deficiency. Both testosterone and dihydrotestosterone inhibited IL-6 production by murine bone
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7. Sex steroids, bone mass, and bone loss. A prospective study of pre-, peri-, and postmenopausal women.
Although bone loss around the time of menopause is driven by estrogen deficiency, the roles of estrogens and androgens in the preservation of skeletal mass at other stages of life are less well understood. To address this issue we studied 231 women between the ages of 32 and 77 with multiple measurements of sex steroids and bone mass over a period of 2-8 yr.
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8. Intracellular and nuclear binding of [3H]dihydrotestosterone in cultured genital skin fibroblasts of patients with severe hypospadias.
Androgens stimulate the development and growth of the male external genitalia. Because hypospadias is the most common congenital defect of the male urethra and because in most cases the cause of this malformation is unknown, we examined the hypothesis that the etiology of the severe forms of this disorder, which is frequently associated with other genital an
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9. Male pseudohermaphroditism due to 17α-hydroxylase deficiency
This is the first report of a male with 17α-hydroxylase deficiency resulting in male pseudohermaphroditism, ambiguous external genitalia, absence of male secondary sexual characteristics, and gynecomastia at puberty. Diagnosis was based on extensive studies of steroid metabolism including the following: low urinary excretion of 17-ketosteroids and 17-hydrox
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10. Steroid disorders in children: Congenital adrenal hyperplasia and apparent mineralocorticoid excess
Our research team and laboratories have concentrated on two inherited endocrine disorders, congenital adrenal hyperplasia (CAH) and apparent mineralocorticoid excess, in thier investigations of the pathophysiology of adrenal steroid hormone disorders in children. CAH refers to a family of inherited disorders in which defects occur in one of the enzymatic ste
The National Academy of Sciences.
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11. Male pseudohermaphroditism presumably due to target organ unresponsiveness to androgens. Deficient 5alpha-dihydrotestosterone binding in cultured skin fibroblasts.
Maximum specific 5alpha-dihydrotestosterone (DHT) binding activity (Bmax) had been measured in intact confluent monolayers representing fibroblast strains derived form nongenital and genital (labium majus) skin of normal individuals and of 11 patients fulfilling the clinicogenetic criteria of complete testicular feminization (TF). Nine labium majus strains f