Annexin A5 Protein
Mostrando 1-12 de 33 artigos, teses e dissertações.
-
1. BthTX-I from Bothrops jararacussu induces apoptosis in human breast cancer cell lines and decreases cancer stem cell subpopulation
ABSTRACT Background: Breast cancer is the neoplasm with both the highest incidence and mortality rate among women worldwide. Given the known snake venom cytotoxicity towards several tumor types, we evaluated the effects of BthTX-I from Bothrops jararacussu on MCF7, SKBR3, and MDAMB231 breast cancer cell lines. Methods: BthTX-I cytotoxicity was determined
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 29/07/2019
-
2. MicroRNA-383-5p inhibits the progression of gastric carcinoma via targeting HDAC9 expression
MicroRNAs (miRNAs), as post-transcriptional regulators, have been reported to be involved in the initiation and progression of various types of cancer, including gastric cancer (GC). The present study aimed to investigate the role of miR-383-5p in gastric carcinogenesis. Cell viability was analyzed using CCK-8 kit. Annexin V-fluorescein isothiocyanate/propid
Braz J Med Biol Res. Publicado em: 29/07/2019
-
3. Kaempferol suppresses human gastric cancer SNU-216 cell proliferation, promotes cell autophagy, but has no influence on cell apoptosis
Gastric cancer remains a serious threat to human health worldwide. Kaempferol is a plant-derived flavonoid compound with a wide range of pharmacological activities. This study aimed to investigate the effects of kaempferol on gastric cancer SNU-216 cell proliferation, apoptosis, and autophagy, as well as underlying potential mechanisms. Viability, proliferat
Braz J Med Biol Res. Publicado em: 14/02/2019
-
4. Rhein induces apoptosis of human gastric cancer SGC-7901 cells via an intrinsic mitochondrial pathway
Rhein is a primary anthraquinone found in the roots of a traditional Chinese herb, rhubarb, and has been shown to have some anticancer effects. The aim of the present study was to investigate the effect of rhein on the apoptosis of the human gastric cancer line SGC-7901 and to identify the mechanism involved. SGC-7901 cells were cultured and treated with rhe
Braz J Med Biol Res. Publicado em: 2012-11
-
5. Mecanismos celulares e moleculares de ação dos glicocorticóides endógenos sobre a mobilização de neutrófilos / Cellular and molecular mechanisms of action of endogenous glucocorticoids on the neutrophil mobilization
We have shown that endogenous glucocorticoids (GE) modulate the rolling and adhesion of neutrophils in vivo, mediating the expression of adhesion molecules on leukocytes and the endothelium. Additionally, the GE control neutrophil maturation in bone marrow and mobilization to peripheral blood. This work aimed to investigate the molecular and cellular mechani
Publicado em: 2010
-
6. Análise das células inflamatórias e da proteína anexina 1 no modelo de artrite experimental e reumatóide humana. / Analysis of the inflammatory cells and annexin 1 protein in the experimental model arthritis and in the human rheumatoid .
Rheumatoid arthritis (RA) is a disease characterized by auto-antibody formation, chronic inflammation and joint oedema resulting in injury of affected cartilage and adjacent bone. In the treatment of this disease glucocorticoids (GC) have been used, wich induce genic expression of anti-inflammatory mediators, such as the annexin 1 protein (Anx-A1), and proin
Publicado em: 2010
-
7. EVALUATION OF RADIOLABELING OF ANNEXIN A5 WITH TECHNETIUM-99m: INFLUENCE OF THE LABELING METHODS ON PHYSICO-CHEMICAL AND BIOLOGICAL PROPERTIES OF THE COMPOUNDS / Avaliação da radiomarcação da anexina A5 com Tecnécio-99m: influência do método de marcação nas propriedades físicos-químicas e biológicas do composto
Annexin A5 (ANXA5) is an intracellular human protein of 36 kDa with high affinity for membrane-bound phosphatidylserine that is selectively exposed on the surface of cells undergoing apoptosis. Apoptosis is important in normal physiology and innumerous pathologic states. Clinical applications for ANXA5 imaging are being developed in oncology, organ transplan
Publicado em: 2009
-
8. Protein decorated Nanoparticules : Small Unilamellar Lipid Vesicules and Block Copolymers Micelles. / Nanoparticules Décorées par des Protéines : Vésicules Lipidiques Unilamellaires et Micelies à Base de Copolymères à Blocs
The formation of protein Annexin-A5 decorated (bio-functionalized) nanoparticles is of particular interest in micelle-mediated target drug delivery, in vivo magnetic resonance imaging, or controlled fabrication of biochips. This work describes an easy access to the synthesis and manipulation of block copolymer nano-objects exhibiting binding ability for the
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 03/07/2008
-
9. Caracterização da DNase da peçonha da serpente Bothrops alternatus : comparação com a DNase acida de mamiferos envolvida em apoptose / Characterization of a Dnase from Bothrops alternatus snake venom : comparision with mamalian acid Dnases involved in apoptosis
Bothrops snake venoms are cytotoxic to a variety of cells (endothelial, smooth muscle, renal and inflammatory cells), and may cause cell death by apoptosis. The venom components implicated in apoptosis include metalloproteinases and L-amino acid oxidase. In contrast, although acidic deoxyribonucleases (DNase II) have been implicated in DNA fragmentation duri
Publicado em: 2008
-
10. Fludarabine induces apoptosis in chronic lymphocytic leukemia - the role of P53, Bcl-2, Bax, Mcl-1, and Bag-1 proteins
The expression of P53, Bcl-2, Bax, Bag-1, and Mcl-1 proteins in CD5/CD20-positive B-chronic lymphocytic leukemia (B-CLL) cells from 30 typical CLL patients was evaluated before and after 48 h of incubation with 10-6 M fludarabine using multiparametric flow cytometric analysis. Protein expression was correlated with annexin V expression, Rai modified clinical
Brazilian Journal of Medical and Biological Research. Publicado em: 2006-03
-
11. Caracterização funcional de genes diferencialmente regulados por glicocorticóides e análise do proteoma em linhagem de glioma sensível à hormônios anti-tumorais glicocorticóides / Functional characterization of glucocorticoid differentially regulated genes and proteomic analysis of the anti-tumoral effect of glucocorticoid in a glucocorticoid-sensitive rat glioma cell line
The glucocorticoid (GC) growth suppression response is controlled through cellular cascades in which the transcription of primary response genes regulates the expression and activity of a diverse set of genes including important factors for cell cycle progression. However, the functional connection between the GC-regulated transcriptional events and cell cyc
Publicado em: 2005
-
12. Key role of the N-terminus of chicken annexin A5 in vesicle aggregation
Annexins are calcium-dependent phospholipid-binding proteins involved in calcium signaling and intracellular membrane trafficking among other functions. Vesicle aggregation is a crucial event to make possible the membrane remodeling but this process is energetically unfavorable, and phospholipid membranes do not aggregate and fuse spontaneously. This issue c
Wiley Subscription Services.