Anti Toxoplasma Gondii Activity
Mostrando 1-12 de 40 artigos, teses e dissertações.
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1. Terapia antiretroviral de inibidores da protease contra Toxoplasma gondii
The introduction of highly active antiretroviral therapy (HAART) has caused a marked reduction in the occurrence and severity of parasitic infections, including the toxoplasmic encephalitis (TE). These changes have been attributed to the restoration of cell-mediated immunity. This study was developed to examine the activity of six antiretroviral protease inh
Rev. Inst. Med. trop. S. Paulo. Publicado em: 2013-02
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2. Bothrops pirajai snake venom L-amino acid oxidase: in vitro effects on infection of Toxoplasma gondii in human foreskin fibroblasts
The effect of an L-amino acid oxidase isolated from Bothrops pirajai snake venom (BpirLAAO-I) was investigated on infection of Toxoplasma gondii in human foreskin fibroblasts (HFF). The cytotoxic activity of BpirLAAO-I on HFF cells showed a dose-dependent toxicity with median cytotoxic dose (TD50) of 11.8 µg/mL. BpirLAAO-I induced considerable dose-dependen
Revista Brasileira de Farmacognosia. Publicado em: 17/06/2011
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3. SÃntese e AvaliaÃÃo das Atividades Anti-Toxoplasma gondii e Antimicrobiana de BenzaldeÃdo 4-Fenil-3-tiossemicarbazonas e Derivados 2[(Fenilmetileno)hidrazono]-3-fenil-4-tiazolidinona-5-substituÃdos
Parasitic diseases, as toxoplasmosis, affect millions of people, and they are responsible for some of the most important and prevalent diseases of humans and domestic animals. These diseases result in considerable morbidity and mortality worldwide, especially in developing countries. The toxoplasmosis is caused by an intracellular parasite, Toxoplasma gondii
Publicado em: 2007
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4. SÃntese e avaliaÃÃo de atividades Anti-Toxoplama gondii e antimicrobiana de Tiossemicarbazidas, 4-Tiazolidinonas e 1,3,4-TiadiazÃis obidos a partir do Ãster 5-Metil-1H-Imidazol-4-Carboxilato de Etila
Toxoplasmosis is an infection caused by Toxoplasma gondii, a protozoan parasite with very complex biology and wide distribution in several geographical areas of the globe. In 2005, our research group published a paper reporting an exceptional anti-T. gondii activity for thiosemicarbazones and arylhydrazono-4-thiazolidinones, with a nitro group in aryl moiety
Publicado em: 2007
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5. Epidemiologia das coccidioses em pequenos ruminantes no município de Ibimirim Estado de Pernambuco, Brasil / Epidemiology of coccidiosis in small ruminants from Ibimirim county, Pernambuco state, Brazil
Small ruminants production is an important activity specially as a protein source, meat, leather, milk and by-products processing throughout the Brazil. However with the lack of technical support in sheep and goat production systems some parasitic disease has been related including coccidiosis. The goal of this study is describe the epidemiology of some cocc
Publicado em: 2007
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6. Mechanisms of killing of Toxoplasma gondii by rat peritoneal macrophages.
Rats are resistant to Toxoplasma infection, and macrophages are thought to mediate this resistance. We performed a series of experiments to investigate the mechanism of the anti-Toxoplasma activity of resident rat peritoneal macrophages. Resident rat peritoneal macrophages killed more than 90% of ingested Toxoplasma gondii in vitro. This capacity was reduced
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7. Inhibition of Toxoplasma gondii protein synthesis by azithromycin.
Azithromycin was shown to specifically inhibit the protein synthesis of Toxoplasma gondii in experimental systems by using free tachyzoites and T. gondii-infected mouse macrophages. RNA synthesis of the parasite was not affected by azithromycin. Inhibition of protein synthesis was also proportional to the relative anti-Toxoplasma activity of three macrolides
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8. Anti-Toxoplasma Activities of 24 Quinolones and Fluoroquinolones In Vitro: Prediction of Activity by Molecular Topology and Virtual Computational Techniques
The apicoplast, a plastid-like organelle of Toxoplasma gondii, is thought to be a unique drug target for quinolones. In this study, we assessed the in vitro activity of quinolones against T. gondii and developed new quantitative structure-activity relationship models able to predict this activity. The anti-Toxoplasma activities of 24 quinolones were examined
American Society for Microbiology.
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9. Gamma Interferon-Induced Inhibition of Toxoplasma gondii in Astrocytes Is Mediated by IGTP
Toxoplasma gondii is an important pathogen in the central nervous system, causing a severe and often fatal encephalitis in patients with AIDS. Gamma interferon (IFN-γ) is the main cytokine preventing reactivation of Toxoplasma encephalitis in the brain. Microglia are important IFN-γ-activated effector cells controlling the growth of T. gondii in the brain
American Society for Microbiology.
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10. In vitro effects of sulfadiazine and its metabolites alone and in combination with pyrimethamine on Toxoplasma gondii.
Sulfadiazine and the metabolites N4-acetyl-sulfadiazine, 4-OH-sulfadiazine, 5-OH-sulfadiazine, 5-OH-glucuronide-sulfadiazine, and 5-OH-sulfate-sulfadiazine were tested separately and in combination with pyrimethamine for the inhibitory activity on Toxoplasma gondii growth in vitro. Except for N4-acetyl-sulfadiazine, all sulfa compounds possessed anti-Toxopla
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11. Comparative activity of macrolides against Toxoplasma gondii demonstrating utility of an in vitro microassay.
The utility of spiramycin for preventing transplacental transmission of toxoplasmosis and the efficacy of conventional macrolides against Toxoplasma gondii are subjects of active debate. An in vitro microassay was developed to determine the relative inhibitory activity against T. gondii of 24 conventional macrolides derived from erythromycin and tylosin (14-
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12. Suppressive effect of secondary Toxoplasma gondii infection on antibody responses in mice.
The effect of the secondary infection with Toxoplasma gondii on antibody responses to unrelated antigens was examined in mice. A reinfection with 5 X 10(3) organisms did not affect either primary anti-sheep erythrocyte antibody responses, or anti-dinitrophenol antibody responses to dinitrophenylated keyhole limpet hemocyanin. With an increase of the reinfect