Antibody Mediated Rejection
Mostrando 1-12 de 27 artigos, teses e dissertações.
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1. Renal transplant patients with preformed anti-HLA antibodies: early biopsy findings and clinical outcomes
Resumo Introdução: A fibrose renal é o desfecho de um processo iniciado no transplante, com reperfusão, isquemia e inflamação precoce, que progride ao longo do tempo com fenômenos imunológicos e não imunológicos. A identificação de marcadores morfológicos e a intervenção precoce poderiam melhorar a função e a sobrevida do enxerto. Objetivo
J. Bras. Nefrol.. Publicado em: 12/09/2019
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2. Issues in solid-organ transplantation in children: translational research from bench to bedside
In this review, we identify important challenges facing physicians responsible for renal and cardiac transplantation in children based on a review of the contemporary medical literature. Regarding pediatric renal transplantation, we discuss the challenge of antibody-mediated rejection, focusing on both acute and chronic antibody-mediated rejection. We review
Clinics. Publicado em: 2014-01
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3. The impact of pretransplant donor-specific antibodies on graft outcome in renal transplantation: a six-year follow-up study
OBJECTIVE: The significance of pretransplant, donor-specific antibodies on long-term patient outcomes is a subject of debate. This study evaluated the impact and the presence or absence of donor-specific antibodies after kidney transplantation on short- and long-term graft outcomes. METHODS: We analyzed the frequency and dynamics of pretransplant donor-speci
Clinics. Publicado em: 2012
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4. Biomarcadores moleculares na rejeição mediada por anticorpos em transplantados renais
Introdução: A rejeição aguda mediada por anticorpos (RAMA) representa atualmente uma importante limitação para o sucesso do transplante renal. Seu diagnóstico é complexo e impreciso e avaliações moleculares com o desenvolvimento de biomarcadores não invasivos podem representar métodos promissores para seu diagnóstico. O objetivo do estudo foi av
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 2011
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5. Glomerular damage as a predictor of renal allograft loss
Interstitial fibrosis and tubular atrophy (IF/TA) are the most common cause of renal graft failure. Chronic transplant glomerulopathy (CTG) is present in approximately 1.5-3.0% of all renal grafts. We retrospectively studied the contribution of CTG and recurrent post-transplant glomerulopathies (RGN) to graft loss. We analyzed 123 patients with chronic renal
Brazilian Journal of Medical and Biological Research. Publicado em: 2010-06
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6. Relevance of anti-HLA monitoring after kidney transplantation: Clinical and anatomopathological study / Relevância da monitorização dos anticorpos anti-HLA após o transplante renal: estudo clínico e anatomopatológico
INTRODUCTION: The aim was to follow prospectively anti-HLA antibodies (Abs) after kidney transplantation and to evaluate their association with acute rejection episodes, C4d staining and graft survival. METHODS: We analyzed 926 sera from 111 transplanted patients until graft lost or during 1 year posttransplant. The antibodies were analyzed using Panel React
Publicado em: 2009
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7. Development of immunological assays to monitor pulmonary allograft rejection.
BACKGROUND--At present the diagnosis of pulmonary allograft rejection is made after examination of transbronchial biopsy specimens; this method is highly invasive. A study was performed to determine whether immunological parameters measured in peripheral blood or bronchoalveolar lavage samples correlate with the histological diagnosis of rejection. METHODS--
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8. Lysis of uninfected and virus-infected cells in vivo: a rejection mechanism in addition to that mediated by natural killer cells.
To examine the lysis of virus-infected cells in vivo, uninfected and lymphocytic choriomeningitis virus (LCMV)-infected L-929 cells were labeled in vitro with [125I]-iododeoxyuridine and implanted intravenously into mice. Natural cytotoxicity against both uninfected and virus-infected cells was demonstrated in normal uninfected mice, but LCMV-infected cells
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9. CCR5 blockade in combination with rapamycin prolongs cardiac allograft survival in mice
Both chemokine receptor 5 (CCR5) blockade and rapamycin (rapa) are effective in modulating transplant immunity and led to prolonged allograft survival, yet a great many grafts were ultimately lost to acute rejection. In this study we examined the inhibition of CCR5 in combination with the treatment with rapa in cardiac transplantation. Fully major histocompa
Blackwell Science Inc.
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10. Immunoglobulin prevents complement-mediated hyperacute rejection in swine-to-primate xenotransplantation.
Immunoglobulins regulate the complement system by activating complement on foreign surfaces and diverting reactive complement proteins away from autologous cell surfaces. Based on this model, we explored the ability of Ig to balance complement activation versus control in a pig-to-primate cardiac xenotransplantation model in which the binding of xenoreactive
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11. Synergy between T-cell immunity and inhibition of paracrine stimulation causes tumor rejection.
During tumor progression, variants may arise that grow more vigorously. The fate of such variants depends upon the balance between aggressiveness of the variant and the strength of the host immunity. Although enhancing host immunity to cancer is a logical objective, eliminating host factors necessary for aggressive growth of the variant should also be consid
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12. Tumors undergoing rejection induced by monoclonal antibodies of the IgG2a isotype contain increased numbers of macrophages activated for a distinctive form of antibody-dependent cytolysis.
Monoclonal antibodies of the IgG2a isotype specifically inhibit the growth of human tumors in nude mice; tumors in mice given no antibody, an antibody of the IgG2a isotype that does bind to the tumor cells, or an antibody of the IgG2b isotype grow progressively. In the present work it is demonstrated that tumors of mice given the IgG2a antibody are essential