Antifungal Peptides
Mostrando 1-12 de 41 artigos, teses e dissertações.
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1. AÇÃO ANTIFÚNGICA DOS PEPTÍDEOS LEPTOCTINAS-1 E -2 ISOLADOS DA SECREÇÃO DA PELE DA RÃ SUL-AMERICANA Leptodactytus pentadactylus (LEPTODACTYLIDAE) / ANTIFUNGAL ACTION OF LEPTOCTINS-1 AND -2 ISALATED FORM SKIN SECRETION OF THE SOUTH AMERICAN FORG Leptodactylus pentadactylus (LEPTODACTYLIDAE).
Nos últimos anos, houve um aumento na incidência de infecções caudadas por fundos que, aliado à ocorrência de fenômenos de resistência fúngica, provocou uma rápida e extensiva busca por novoas drogas para o tratamento de micoses. Peptídeos antimicrobianos são componentes do sistema imune de vertebrados e invertebrados e constituem a primeira linh
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 09/12/2010
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2. Antifungal and antitumor models of bioactive protective peptides
Peptídeos são moléculas particularmente reativas produzidas por uma grande variedade de espécies, aptos a exercer um número de funções em organismos uni-e multicelulares como mediadores, agonistas e substâncias regulatórias. Alguns deles exercem efeitos citotóxicos em células outras das que os produzem, e podem ter um papel controlando subpopulaç
Anais da Academia Brasileira de Ciências. Publicado em: 2009-09
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3. Polyketide biosynthetic gene bioprospection in metagenomic DNA from Atlantic Forest soil. / Bioprospecção de genes biossintéticos de policetídeos em DNA metagenômico de solo de Mata Atlântica.
The Brazilian Atlantic Forest is considered as one of the most important reservoir of biodiversity in the planet. This biome is extremely important for its richness of plant and animal species but although with their composition and interactions poorly known and unexplored from a microbiological perspective. One gram of soil can contain near 10 billion micro
Publicado em: 2009
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4. Estudos estruturais de histatina-5 e seu análogo, TOAC0-histatina-5: interação com metais e sistemas biomiméticos / Structural studies of Histatin-5 and its analogue, TOAC0-Histatin-5: interaction with metals and biomimetic systems
The mechanism of action of histatin-5 (Hst-5), an antifungal antimicrobial peptide from human saliva is not completely clarified. Circular dichroism (CD), fluorescence, and electron paramagnetic resonance (EPR) were used to examine the conformational behavior of Hst-5 and its analogue containing the paramagnetic amino acid TOAC at the N-terminus (TOAC0-Hst-5
Publicado em: 2008
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5. Mecanismo de ação da microplusina, um peptídeo quelante de cobre com atividade antimicrobiana. / Action mechanism of microplusin, a copper chelating peptide with antimicrobial activity.
Antimicrobial peptides (AMPs) take part of innate immune mechanisms against infections. Microplusin is a 10,204 Da AMP, isolated from cell-free hemolymph and eggs of the tick Rhipicephalus (Boophilus) microplus. It is an anionic AMP at physiological pH, with six cysteine residues forming three disulfide bridges and seven histidine residues clustered mainly a
Publicado em: 2008
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6. Estudo da ação da peçonha do escorpião brasileiro Tityus serrulatuse de suas frações na inibição do crescimento de fungos / Antifungal properties of Tityus serrulatus scorpion venom and its major toxin TsTx-I.
Antimicrobial peptides appear to be ubiquitous and multipotent components of the innate immune defense arsenal used by both prokaryotic and eukaryotic organisms. They are used in the first line of immune defense. In this work, we evaluate the effects of Tityus serrulatus venom (Tsv) and its major toxin TsTX-I, a -neurotoxin, on fungi growth. TsTX-I was isola
Publicado em: 2007
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7. PROTEIN-PROTEIN INTERACTION ANALYSIS OF THE DEFENSIN PSD1 FROM PISUM SATIVUM WITH NEUROSPORA CRASSA PROTEINS / ANÁLISE DA INTERAÇÃO PROTÉICA DA DEFENSINA PSD1 DE PISUM SATIVUM COM PROTEÍNAS DO FUNGO NEUROSPORA CRASSA
Plant defensins, innate components of the plant immune system, are cationic, antifungal peptides, with a cysteine- rich primary structure. Evidence from the literature demonstrated that fungus membrane patches containing complex sphingolipids, mannosyldiinositolphosphorylceramide and glucosylceramides, are selective binding sites for the plant defensins isol
Publicado em: 2006
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8. Role of protein present in the ink released by-the-sea slug Aplysia dactylomela Rang in 1828 in defense mechanisms of the animal / Papel de proteínas presentes na tinta liberada pela lesma-do-mar Aplysia dactylomela Rang 1828 nos mecanismos de defesa do animal
The marine gastropod Aplysia dactylomela is known to release a purple ink when it is plagued. How has no external structure of protection, it is believed that secretion, rich in biologically active substances, participate in the chemical defense of the animal. The ink is composed of pigments, proteins and low molecular weight substances. The pigments of ink
Publicado em: 2005
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9. In Vitro Assessment of Antifungal Therapeutic Potential of Salivary Histatin-5, Two Variants of Histatin-5, and Salivary Mucin (MUC7) Domain 1
Human salivary histatin-5 (Hsn-5) is a 24-residue peptide that possesses potent antifungal activity in vitro. The MUC7 gene encodes human salivary low-molecular-weight mucin (MG2). The candidacidal activity of MUC7 domain 1 (MUC7 D1, the N-terminal 51 amino acid residues of MUC7) in vitro has also been demonstrated. In this study, we have investigated the an
American Society for Microbiology.
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10. Drosophila host defense: Differential induction of antimicrobial peptide genes after infection by various classes of microorganisms
Insects respond to microbial infection by the rapid and transient expression of several genes encoding potent antimicrobial peptides. Herein we demonstrate that this antimicrobial response of Drosophila is not aspecific but can discriminate between various classes of microorganisms. We first observe that the genes encoding antibacterial and antifungal peptid
The National Academy of Sciences of the USA.
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11. Amphotericin B- and Fluconazole-Resistant Candida spp., Aspergillus fumigatus, and Other Newly Emerging Pathogenic Fungi Are Susceptible to Basic Antifungal Peptides
The present study shows that a number of basic antifungal peptides, including human salivary histatin 5, a designed histatin analog designated dhvar4, and a peptide from frog skin, PGLa, are active against amphotericin B-resistant Candida albicans, Candida krusei, and Aspergillus fumigatus strains and against a fluconazole-resistant Candida glabrata isolate.
American Society for Microbiology.
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12. A recessive mutation, immune deficiency (imd), defines two distinct control pathways in the Drosophila host defense.
In this paper we report a recessive mutation, immune deficiency (imd), that impairs the inducibility of all genes encoding antibacterial peptides during the immune response of Drosophila. When challenged with bacteria, flies carrying this mutation show a lower survival rate than wild-type flies. We also report that, in contrast to the antibacterial peptides,