Antiganglioside Antibodies
Mostrando 1-12 de 24 artigos, teses e dissertações.
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1. Preparação e caracterização de lipossomas com a superficie modificada com gangliosidios para uso em imunoterapia
The pharmacological importance of gangliosides has increased in the last few years due to the identification of these compounds as antigens, producing antiganglioside antibodies, which may be involved in autoimmune diseases or neuropathy. Studies in ganglioside literature encompass their properties and functions in the neuronal membranes as well as their pha
Publicado em: 2001
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2. Guillain-Barré Syndrome- and Miller Fisher Syndrome-Associated Campylobacter jejuni Lipopolysaccharides Induce Anti-GM1 and Anti-GQ1b Antibodies in Rabbits
Campylobacter jejuni infections are thought to induce antiganglioside antibodies in patients with Guillain-Barré syndrome (GBS) and Miller Fisher syndrome (MFS) by molecular mimicry between C. jejuni lipopolysaccharides (LPS) and gangliosides. We used purified LPS fractions from five Campylobacter strains to induce antiganglioside responses in rabbits. The
American Society for Microbiology.
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3. Ganglioside Mimicry of Campylobacter jejuni Lipopolysaccharides Determines Antiganglioside Specificity in Rabbits
The core oligosaccharides of Campylobacter jejuni lipopolysaccharides (LPS) display molecular mimicry with gangliosides. Cross-reactive anti-LPS-antiganglioside antibodies have been implicated to show a crucial role in the pathogenesis of the Guillain-Barré and Miller Fisher syndrome. The specificity of the antiganglioside response is thought to depend on t
American Society for Microbiology.
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4. The crucial role of Campylobacter jejuni genes in anti-ganglioside antibody induction in Guillain-Barré syndrome
Molecular mimicry of Campylobacter jejuni lipo-oligosaccharides (LOS) with gangliosides in nervous tissue is considered to induce cross-reactive antibodies that lead to Guillain-Barré syndrome (GBS), an acute polyneuropathy. To determine whether specific bacterial genes are crucial for the biosynthesis of ganglioside-like structures and the induction of ant
American Society for Clinical Investigation.
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5. In Vivo Phase Variation and Serologic Response to Lipooligosaccharide of Campylobacter jejuni in Experimental Human Infection
Some Campylobacter jejuni strains which exhibit mimicry of gangliosides in their lipooligosaccharides (LOSs) are associated with development of Guillain-Barré syndrome, which complicates the selection of a suitable C. jejuni strain in a live-attenuated vaccine. C. jejuni 81-176 is the most well characterized strain available, but structurally, LOS of C. jej
American Society for Microbiology.
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6. Antiganglioside antibodies in peripheral neuropathies.
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7. Antiganglioside antibodies in toxic oil syndrome.
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8. Do anti-ganglioside antibodies cause human peripheral neuropathies?
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9. Antiganglioside antibodies in the CSF of patients with motor neuron diseases and Guillain-Barré syndrome.
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10. MATTERS ARISING: Antiganglioside antibodies in the CSF of patients with motor neuron diseases and Guillain-Barré syndrome
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11. Tolerance to Self Gangliosides Is the Major Factor Restricting the Antibody Response to Lipopolysaccharide Core Oligosaccharides in Campylobacter jejuni Strains Associated with Guillain-Barré Syndrome
Guillain-Barré syndrome following Campylobacter jejuni infection is frequently associated with anti-ganglioside autoantibodies mediated by molecular mimicry with ganglioside-like oligosaccharides on bacterial lipopolysaccharide (LPS). The regulation of antibody responses to these T-cell-independent antigens is poorly understood, and only a minority of Campy
American Society for Microbiology.
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12. Pathophysiological actions of neuropathy-related anti-ganglioside antibodies at the neuromuscular junction
The outer leaflet of neuronal membranes is highly enriched in gangliosides. Therefore, specific neuronal roles have been attributed to this family of sialylated glycosphingolipids, e.g. in modulation of ion channels and transporters, neuronal interaction and recognition, temperature adaptation, Ca2+ homeostasis, axonal growth, (para)node of Ranvier stability
Blackwell Science Inc.