Antimonial
Mostrando 1-12 de 81 artigos, teses e dissertações.
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1. Leishmanioses: sua configuração histórica no Brasil com ênfase na doença visceral nos anos 1930 a 1960
Resumo Casos pioneiros de leishmaniose cutânea e mucocutânea nas Américas foram descritos em São Paulo, em 1909; somente em 1934, um patologista do Serviço de Febre Amarela encontrou a leishmaniose visceral no Brasil. Processos históricos concernentes a essas formas ganharam mais vigor institucional nos anos 1930. Se a Comissão para o Estudo da Leishm
Bol. Mus. Para. Emílio Goeldi. Ciênc. hum.. Publicado em: 26/08/2019
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2. American tegumentary leishmaniasis: severe side effects of pentavalent antimonial in a patient with chronic renal failure
Abstract: Pentavalent antimonials are the first-line drug treatment for American tegumentary leishmaniasis. We report on a patient with chronic renal failure on hemodialysis who presented with cutaneous lesions of leishmaniasis for four months. The patient was treated with intravenous meglumine under strict nephrological surveillance, but cardiotoxicity, acu
An. Bras. Dermatol.. Publicado em: 29/07/2019
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3. A randomized, open-label clinical trial comparing the long-term effects of miltefosine and meglumine antimoniate for mucosal leishmaniasis
Abstract INTRODUCTION: The treatment of mucosal leishmaniasis (ML) is difficult due to the toxicity and route of administration of standard drugs. Miltefosine is an oral agent used for leishmaniasis treatment; however, no data exist regarding its use for ML in Brazil. In this study, we aimed to evaluate the efficacy of miltefosine for ML treatment compared
Rev. Soc. Bras. Med. Trop.. Publicado em: 28/03/2019
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4. Pharmacokinetics of neutron-irradiated meglumine antimoniate in Leishmania amazonensis-infected BALB/c mice
Abstract Background: Cutaneous leishmaniasis (CL) is a parasitic disease caused by the protozoan Leishmania spp. Pentavalent antimonial agents have been used as an effective therapy, despite their side effects and resistant cases. Their pharmacokinetics remain largely unexplored. This study aimed to investigate the pharmacokinetic profile of meglumine anti
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 11/03/2019
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5. Visceral leishmaniasis in a Brazilian endemic area: an overview of occurrence, HIV coinfection and lethality
ABSTRACT The Brazilian municipality of Rondonópolis, Mato Grosso State, represents an important visceral leishmaniasis (VL) endemic area. This study described epidemiological and clinical aspects of the occurrence, VL/HIV coinfection and lethality related to VL in Rondonópolis. Data from autochthonous cases reported between 2011 and 2016 were obtained from
Rev. Inst. Med. trop. S. Paulo. Publicado em: 08/03/2018
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6. American tegumentary leishmaniasis: diagnostic and treatment challenges in a clinical case
ABSTRACT This clinical case presents a patient with a raised and ulcerative lesion with erythematous edges in the mouth, on the lower lip that was unsuccessfully treated as herpes labialis. Clinical data and laboratory tests (Montenegro skin test, indirect immunofluorescence, direct parasite search and polymerase chain reaction) led to the diagnosis of Ameri
Rev. Inst. Med. trop. S. Paulo. Publicado em: 15/02/2018
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7. Towards a standard protocol for antimony intralesional infiltration technique for cutaneous leishmaniasis treatment
BACKGROUND Despite its recognised toxicity, antimonial therapy continues to be the first-line drug for cutaneous leishmaniasis (CL) treatment. Intralesional administration of meglumine antimoniate (MA) represents an alternative that could reduce the systemic absorption of the drug and its side effects. OBJECTIVES This study aims to validate the standard op
Mem. Inst. Oswaldo Cruz. Publicado em: 2018-02
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8. American tegumentary leishmaniasis: epidemiological and molecular characterization of prevalent Leishmania species in the State of Tocantins, Brazil, 2011-2015
ABSTRACT Determination of the epidemiological profile of the American tegumentary leishmaniasis (ATL) and identification of Leishmania species that are prevalent in the State of Tocantins were carried out through a retrospective and descriptive study based on data reported in SINAN, in the period from 2011 to 2015. Molecular techniques such as PCR-RFLP and P
Rev. Inst. Med. trop. S. Paulo. Publicado em: 21/12/2017
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9. Efficacy and safety of amphotericin B deoxycholate versus N-methylglucamine antimoniate in pediatric visceral leishmaniasis: an open-label, randomized, and controlled pilot trial in Brazil
ABSTRACT INTRODUCTION Despite their high toxicity, antimonials and amphotericin B deoxycholate are commonly used for treating visceral leishmaniasis (VL). Few studies showing conflictive data about their efficacy and adverse events in pediatric population are available. This study aimed to evaluate efficacy and safety of amphotericin B deoxycholate vs. tha
Rev. Soc. Bras. Med. Trop.. Publicado em: 2017-02
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10. Multivariate optimization of a method for antimony determination by hydride generation atomic fluorescence spectrometry in hair samples of patients undergoing chemotherapy against Leishmaniasis
ABSTRACT A method was developed for determination of total antimony in hair samples from patients undergoing chemotherapy against Leishmaniasis based on the administration of pentavalent antimonial drugs. The method is based on microwave assisted digestion of the samples in a pressurized system, reduction of Sb5+ to Sb3+ with KI solution (10% w/v) in ascorbi
An. Acad. Bras. Ciênc.. Publicado em: 25/08/2016
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11. Antimonial drugs entrapped into phosphatidylserine liposomes: physicochemical evaluation and antileishmanial activity
Abstract: INTRODUCTION: Leishmaniasis is a disease caused by the protozoan Leishmania that resides mainly in mononuclear phagocytic system tissues. Pentavalent antimonials are the main treatment option, although these drugs have toxic side effects and high resistance rates. A potentially alternative and more effective therapeutic strategy is to use liposom
Rev. Soc. Bras. Med. Trop.. Publicado em: 2016-04
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12. Leishmania (Viannia) naiffi: rare enough to be neglected?
In the Brazilian Amazon, American tegumentary leishmaniasis (ATL) is endemic and presents a wide spectrum of clinical manifestations due, in part, to the circulation of at least seven Leishmaniaspecies. Few reports of Leishmania (Viannia) naiffiinfection suggest that its occurrence is uncommon and the reported cases present a benign clinical course and a goo
Mem. Inst. Oswaldo Cruz. Publicado em: 2015-09