Antituberculosis Drugs Bioavailability
Mostrando 1-3 de 3 artigos, teses e dissertações.
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1. Intestinal permeability and malabsorption of rifampin and isoniazid in active pulmonary tuberculosis
Low antimycobacterial drug concentrations have been observed in tuberculosis (TB) patients under treatment. The lactulose/mannitol urinary excretion test (L/M), normally used to measure intestinal permeability, may be useful to assess drug absorption. The objective of this research was to study intestinal absorptive function and bioavailability of rifampin a
Brazilian Journal of Infectious Diseases. Publicado em: 2006-12
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2. Intestinal permeability study in active pulmonary tuberculosis / Estudo da permeabilidade intestinal em pacientes com tuberculose pulmonar ativa
Subtherapeutic antimycobacterial drugs levels have been observed during treatment of patients with tuberculosis and in HIV coinfected. It may facilitate the development of M. tuberculosis resistant strains. Malabsorption may be one of the underlyne cause. It has been documented in tuberculosis patients associated to malnutrition, alchoolics, diabetes, AIDS a
Publicado em: 2003
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3. Decreased Bioavailability of Rifampin and Other Antituberculosis Drugs in Patients with Advanced Human Immunodeficiency Virus Disease
We evaluated the effects of human immunodeficiency virus (HIV) disease on pharmacokinetics of antituberculosis medications by measuring concentrations of isoniazid and rifampin in blood and of pyrazinamide and ethambutol in urine. Peak concentration and exposure were reduced for rifampin, and rapid acetylators of isoniazid had lower drug levels. HIV and HIV-
American Society for Microbiology.