Antitumor Candidate
Mostrando 1-9 de 9 artigos, teses e dissertações.
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1. Cytotoxic and pro-apoptotic action of MjTX-I, a phospholipase A2 isolated from Bothrops moojeni snake venom, towards leukemic cells
Abstract Background: Chronic myeloid leukemia (CML) is a BCR-ABL1+ myeloproliferative neoplasm marked by increased myeloproliferation and presence of leukemic cells resistant to apoptosis. The current first-line therapy for CML is administration of the tyrosine kinase inhibitors imatinib mesylate, dasatinib or nilotinib. Although effective to treat CML, som
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 24/01/2019
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2. In vivo chemotherapeutic insight of a novel isocoumarin (3-hexyl-5,7-dimethoxy-isochromen-1-one): Genotoxicity, cell death induction, leukometry and phagocytic evaluation
Abstract Chemotherapy is one of the major approaches for the treatment of cancer. Therefore, the development of new chemotherapy drugs is an important aspect of medicinal chemistry. Chemotherapeutic agents include isocoumarins, which are privileged structures with potential antitumoral activity. Herein, a new 3-substituted isocoumarin was synthesized from 2-
Genet. Mol. Biol.. Publicado em: 2017-09
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3. Avaliação pré-clínica da farmacocinética e da toxicidade aguda em roedores do candidato a fármaco antitumoral LaSOM 65 / Pre-clinical evaluation of the pharmacokinetics and acute toxicity in rodents of the anticancer candidate LaSOM 65
Objetivo: Contribuir para o desenvolvimento do candidato a antitumoral (LaSOM 65) através da avaliação farmacocinética pré-clínica em roedores de diferentes doses pelas vias i.v., p.o e i.p. e avaliação da toxicidade aguda do composto. Metodologia: LaSOM 65 foi administrado a ratos Wistar nas doses de 1 mg/kg i.v. bolus (n = 8), 10 e 30 mg/kg p.o. e
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 2012
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4. Assessment of estrogenic, mutagenic and antimutagenic activity of nemorosone
Currently, a wide range of research involving natural products is focused on the discovery of new drugs in many different therapeutic areas. A great number of the synthetic compounds on the market were derived from natural products, especially plants. Nemorosone is the major constituent of the floral resin of Clusia rosea Jacq., Clusiaceae, and in Cuban prop
Revista Brasileira de Farmacognosia. Publicado em: 26/08/2011
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5. Avaliação farmacocinética e do metabolismo in vivo e in vitro do candidato a antitumoral AC04 / Antitumor candidate ac04 pharmacokinetics and in vitro-in vivo metabolism evaluation
Objetivo: AC04 é um derivado acridínico com elevada atividade contra tumores sólidos em camundongos. O objetivo deste trabalho foi investigar a farmacocinética no plasma e a distribuição tecidual em ratos Wistar após administração i.v. bolus bem como o metabolismo in vitro e in vivo do AC04. Metodologia: AC04 foi submetido à oxidação in vitro com
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 2011
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6. Isolation of a high-affinity stable single-chain Fv specific for mesothelin from DNA-immunized mice by phage display and construction of a recombinant immunotoxin with anti-tumor activity
Mesothelin is a differentiation antigen present on the surface of ovarian cancers, mesotheliomas, and several other types of human cancers. Because among normal tissues, mesothelin is present only on mesothelial cells, it represents a good target for antibody-mediated delivery of cytotoxic agents. In the present study mice were immunized with an eukaryotic e
National Academy of Sciences.
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7. Toward optimized carbohydrate-based anticancer vaccines: Epitope clustering, carrier structure, and adjuvant all influence antibody responses to Lewisy conjugates in mice
The feasibility of using carbohydrate-based vaccines for the immunotherapy of cancer is being actively explored at the present time. Although a number of clinical trials have already been conducted with glycoconjugate vaccines, the optimal design and composition of the vaccines has yet to be determined. Among the candidate antigens being examined is Lew
The National Academy of Sciences.
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8. Flavopiridol, a novel cyclin-dependent kinase inhibitor, suppresses the growth of head and neck squamous cell carcinomas by inducing apoptosis.
Flavopiridol (HMR 1275) has been identified recently as a novel antineoplastic agent in the primary screen conducted by the Developmental Therapeutics Program, National Cancer Institute. Flavopiridol inhibits most cyclin-dependent kinases (cdks) and displays unique anticancer properties. Here, we investigated whether this compound was effective against head
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9. Chimeric papillomavirus virus-like particles elicit antitumor immunity against the E7 oncoprotein in an HPV16 tumor model
Papillomavirus-like particles (VLPs) are a promising prophylactic vaccine candidate to prevent human papillomavirus (HPV) infections and associated epithelial neoplasia. However, they are unlikely to have therapeutic effects because the virion capsid proteins are not detected in the proliferating cells of the infected epithelia or in cervical carcinomas. To
The National Academy of Sciences.