Antitumor Drug
Mostrando 1-12 de 235 artigos, teses e dissertações.
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1. Multifunctionality of βCD/Ofloxacin and HPβCD/Ofloxacin Complexes: Improvement of the Antimicrobial Activity and Apoptosis Induction on Lung Adenocarcinoma A549 Cells
The ofloxacin (OFLOX) is a second-generation synthetic antibiotic that can be classified as a multifunctional drug, but is a poorly soluble drug, which influences its efficiency. The inclusion complexes of OFLOX with β-cyclodextrin (βCD) or hydroxypropyl-β-cyclodextrin (HPβCD) can improve the chemical characteristics of the drug; however, studies showing
J. Braz. Chem. Soc.. Publicado em: 2020-12
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2. Preparation and evaluation of 2-methoxyestradiol-loaded pH-sensitive liposomes
The development and clinical application of 2-methoxyestradiol (2-ME) as a new type of antitumor drug are limited due to its poor solubility, rapid metabolism in vivo, and large oral dosage. 2-ME-loaded pH-sensitive liposomes (2-ME-PSLs) was prepared containing the lipids, Lipoid E-80 (E-80), cholesteryl hemisuccinate (CHEMS), and cholesterol (CHOL) via thin
Braz. J. Pharm. Sci.. Publicado em: 03/10/2019
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3. Antinociceptive and anti-inflammatory activities of a triterpene-rich fraction from Himatanthus drasticus
Himatanthus drasticus (Mart.) Plumel belongs to the Apocynaceae family and the latex from its trunk bark (Hd) is known as “janaguba milk”. This latex is widely used in Northeast Brazil, mainly in the Cariri region, for its gastroprotective, anti-inflammatory, and antitumor properties. The objective of this study was to investigate a triterpene-rich fract
Braz J Med Biol Res. Publicado em: 16/05/2019
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4. Toona sinensis: a comprehensive review on its traditional usages, phytochemisty, pharmacology and toxicology
Abstract Toona sinensis (Juss.) M.Roem, Meliaceae, a deciduous plant native to eastern and southeastern Asia, is widely used in Traditional Chinese Medicine. This paper was aimed to summarize the current advances in traditional usage, phytochemistry, pharmacology and toxicology of T. sinensis. In this review, various types of data of T. sinensis are discusse
Rev. bras. farmacogn.. Publicado em: 2019-02
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5. Cytotoxic and pro-apoptotic action of MjTX-I, a phospholipase A2 isolated from Bothrops moojeni snake venom, towards leukemic cells
Abstract Background: Chronic myeloid leukemia (CML) is a BCR-ABL1+ myeloproliferative neoplasm marked by increased myeloproliferation and presence of leukemic cells resistant to apoptosis. The current first-line therapy for CML is administration of the tyrosine kinase inhibitors imatinib mesylate, dasatinib or nilotinib. Although effective to treat CML, som
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 24/01/2019
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6. Natural products as new antimitotic compounds for anticancer drug development
Cell cycle control genes are frequently mutated in cancer cells, which usually display higher rates of proliferation than normal cells. Dysregulated mitosis leads to genomic instability, which contributes to tumor progression and aggressiveness. Many drugs that disrupt mitosis have been studied because they induce cell cycle arrest and tumor cell death. Thes
Clinics. Publicado em: 10/12/2018
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7. DNA repair pathways and cisplatin resistance: an intimate relationship
The main goal of chemotherapeutic drugs is to induce massive cell death in tumors. Cisplatin is an antitumor drug widely used to treat several types of cancer. Despite its remarkable efficiency, most tumors show intrinsic or acquired drug resistance. The primary biological target of cisplatin is genomic DNA, and it causes a plethora of DNA lesions that block
Clinics. Publicado em: 06/09/2018
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8. Ameliorating the antitumor activity of lenalidomide using PLGA nanoparticles for the treatment of multiple myeloma
Abstract Lenalidomide (LND) is an anti-cancer drug and an effective derivative of thalidomide used for multiple myeloma therapy. Because of its poor solubility in water, LND is known to cause low oral bioavailability (below 33%), and as a direct consequence of this, the dosing frequency is extended thus increasing risk of toxicity. To improve its bioavailabi
Braz. J. Pharm. Sci.. Publicado em: 22/06/2017
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9. Ocean Dwelling Actinobacteria as Source of Antitumor Compounds
ABSTRACT Extending over decades, research has been of great focus and enormous progress on exploring the ocean for natural products from marine actinobacteria. Attraction towards alternative medicine has led to improvements in natural product discovery. With great potential to survive in extreme environments, marine actinobacteria, efficiently produce an arr
Braz. arch. biol. technol.. Publicado em: 01/08/2016
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10. Histological changes caused by meclofenamic acid in androgen independent prostate cancer tumors: evaluation in a mouse model
ABSTRACT Meclofenamic acid is a nonsteroidal anti-inflammatory drug that has shown therapeutic potential for different types of cancers, including androgen-independent prostate neoplasms. The antitumor effect of diverse nonsteroidal anti-inflammatory drugs has been shown to be accompanied by histological and molecular changes that are responsible for this be
Int. braz j urol.. Publicado em: 2015-10
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11. Evaluation of mutagenicity and metabolism-mediated cytotoxicity of the naphthoquinone 5-methoxy-3,4-dehydroxanthomegnin from Paepalanthus latipes
A large number of quinones have been associated with antitumor, antibacterial, antimalarial, and antifungal activities. Results of previous studies of 5-methoxy-3,4-dehydroxanthomegnin, a naphthoquinone isolated from Paepalanthus latipes Silveira, Eriocaulaceae, revealed antitumor, antibacterial, immunomodulatory, and antioxidant activities. In this study, w
Rev. bras. farmacogn.. Publicado em: 2015-02
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12. Complexos metálicos de hidrazonas, tiossemicarbazonas e lapachol: atividade farmacológica e avaliação de relações estrutura-atividade
The present work comprises the synthesis and characterization of metal compounds with bioactive ligands and the study of their pharmacological profile. Anti-inflammatory, antimicrobial, antiparasitic and antitumor drug candidates were designed. Complex [Zn(LASSBio-466)H2O]2 was synthesized with salicylaldehyde-2-chlorobenzoyl hydrazone (H2LASSBio-466), while
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 10/02/2012