Arilpiperazinas
Mostrando 1-2 de 2 artigos, teses e dissertações.
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1. Synthesis of a novel series of 4-arylpiperazinyl derivatives linked to a 2-(pyridin-3-yl)-1H-benzimidazole as new Delavirdine analogues
A síntese de uma série de arilpiperazinas ligadas à estrutura 2-(piridina-3-il)-1H-benzo[d]imidazol, através de um linker alquílico é relatada. Os novos derivados 1-(2-(4-arilpiperazina-1-il)alquil)-2-(piridina-3-il)-1H-benzimidazol são estruturalmente relacionados à droga anti-HIV-1 Delavirdina e pertencem à família bis(heteroaril)piperazinas (BHA
Journal of the Brazilian Chemical Society. Publicado em: 2010
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2. Molecular modeling of arylpiperazine compounds and their interactions with the 5-HT1A receptor / Modelagem molecular de compostos arilpiperazínicos e suas interações com o receptor 5-HT1A
Selective serotonin reuptake inhibitors (SSRIs) are the most important class of antidepressants in current clinical use. However, they present the serious drawback of a delay of two to six weeks in the onset of therapeutic effect. Clinical studies have shown that when a 5-HT1A receptor antagonist is administrated along with a SSRI, an increase of extracellul
Publicado em: 2008