Aromatase Inhibitor
Mostrando 1-12 de 14 artigos, teses e dissertações.
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1. Perfil dos esteroides gonadais e expressão dos hormônios folículo estimulante (FSH) e luteinizante (LH) durante a inversão sexual de Epinephelus marginatus (Teleostei: Serranidae), hermafrodita protogínico, utilizando-se inibidor de aromatase / Gonadal steroids profile and expression of follicle-stimulating (FSH) and luteinizing (LH) hormones during the sex reversal of Epinephelus marginatus (Teleostei: Serranidae) hermaphroditic protogynous, using aromatase inhibitor
A plasticidade do desenvolvimento gonadal em peixes, que contrasta com os padrões mais estáveis encontrados nos demais vertebrados, deu origem a várias questões intrigantes relativas tanto ao seu significado adaptativo quanto aos fatores genéticos e fisiológicos que modulam o processo. A inversão do sexo em peixes hermafroditas seqüenciais (protândr
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 03/08/2012
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2. Testosterone therapy delays cardiomyocyte aging via an androgen receptor-independent pathway
The testicular feminized (Tfm) mouse carries a nonfunctional androgen receptor (AR) and reduced circulating testosterone levels. We used Tfm and castrated mice to determine whether testosterone modulates markers of aging in cardiomyocytes via its classic AR-dependent pathway or conversion to estradiol. Male littermates and Tfm mice were divided into 6 experi
Brazilian Journal of Medical and Biological Research. Publicado em: 2011-11
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3. Ação do inibidor da aromatase no tratamento do leiomioma uterino na menacme / Use of aromatase inhibitor for leiomyoma of the uterus treatment in patient during menacme
Foram estudadas 20 pacientes na menacme portadoras de leiomioma uterino, sintomáticas, que utilizaram anastrozol na dose 1 mg/dia por três meses consecutivos. Durante o tratamento acompanhou-se o volume do conjunto úteroleiomiomas com ultra-sonografia, no momento inicial e após um mês e três meses do início do uso da medicação. Além disso, foi obse
Publicado em: 2007
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4. Química e atividades biológicas de Hancornia speciosa Gomes (Apocynaceae):: inibição da enzima conversora de angiotensina (ECA) e efeito na quimioprevenção de câncer
Hancornia speciosa Gomes (Apocynaceae) is a plant species found in cerrado, a savannahlike vegetation, popularly used to treat hypertension and inflammatory processes. Its potential anti-hypertensive activity has been previously demonstrated by in vitro inhibition of angiotensin converting enzyme (ACE) and vasodilatation in rat aortic rings. Several studies
Publicado em: 2007
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5. Testosterone inhibits early atherogenesis by conversion to estradiol: Critical role of aromatase
The effects of testosterone on early atherogenesis and the role of aromatase, an enzyme that converts testosterone to estrogens, were assessed in low density lipoprotein receptor-deficient male mice fed a Western diet. Castration of male mice increased the extent of fatty streak lesion formation in the aortic origin compared with testes-intact animals.
The National Academy of Sciences.
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6. Aromatase inhibitor cuts risk of recurrence of breast cancer
BMJ Publishing Group Ltd..
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7. Conversion of a 3-desoxysteroid to 3-desoxyestrogen by human placental aromatase.
Human placental aromatase is a cytochrome P-450 enzyme system which converts androgens to estrogens by three successive oxidative reactions. The first two steps have been shown to be hydroxylations at the androgen 19-carbon, but the third step remains unknown. A leading theory for the third step involves ferric peroxide attack on the 19-oxo group to produce
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8. Testosterone attenuates expression of vascular cell adhesion molecule-1 by conversion to estradiol by aromatase in endothelial cells: Implications in atherosclerosis
We previously reported that testosterone attenuated atherogenesis in LDLR−/− male mice, and that this effect of testosterone was most likely caused by its conversion to estradiol. Estradiol inhibits vascular cell adhesion molecule-1 (VCAM-1) expression, and expression of VCAM-1 is one of the early events in atherogenesis. We assessed the cellular mechani
The National Academy of Sciences.
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9. Tamoxifen: the drug that came in from the cold
Despite the perception of many oncologists that tamoxifen is an inferior drug, and should be substituted by an aromatase inhibitor in post-menopausal women, the current evidence strongly supports the view that AIs should be used 2–3 years after tamoxifen to achieve the maximal overall survival (OS) advantage.
Nature Publishing Group.
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10. Signaling through estrogen receptors modulates telomerase activity in human prostate cancer
Sex steroid hormone receptors play a central role in all stages of prostate cancer. Here, we tested whether estrogen receptor (ER) signaling contributes to telomerase activation, an early event in prostate tumorigenesis. Following 17β-estradiol (E2) treatment, both mRNA encoding the catalytic subunit of human telomerase (hTERT) and telomerase activity were
American Society for Clinical Investigation.
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11. Estrogen-inducible, sex-specific expression of brain-derived neurotrophic factor mRNA in a forebrain song control nucleus of the juvenile zebra finch
The expression of brain-derived neurotrophic factor (BDNF) mRNA is increased significantly within the high vocal center (HVc) of male but not female zebra finches from posthatching day 30–35 on. The population of HVc cells expressing BDNF mRNA included 35% of the neurons projecting to the nucleus robustus of the archistriatum (RA). In the RA and in RA-proj
The National Academy of Sciences.
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12. Sex hormones, acting on the TERT gene, increase telomerase activity in human primary hematopoietic cells
Androgens have been used in the treatment of bone marrow failure syndromes without a clear understanding of their mechanism of action. Blood counts of patients with dyskeratosis congenita or aplastic anemia with mutations in telomerase genes can improve with androgen therapy. Here we observed that exposure in vitro of normal peripheral blood lymphocytes and
American Society of Hematology.