Artificial Synapse
Mostrando 1-9 de 9 artigos, teses e dissertações.
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1. Comportamento complexo em centros geradores de padrões / Complex behavior in central pattern generators
Realizamos simulações computacionais de modelos da atividade elétrica de centros geradores de padrões para investigar o fato experimental de organismos vivos utilizarem neurônios caóticos para produzir padrões periódicos. Centros geradores de padrões biológicos produzem atividades motoras periódicas que devem ser robustas a pequenas flutuações d
Publicado em: 2005
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2. Neuroligin-1 performs neurexin-dependent and neurexin-independent functions in synapse validation
Postsynaptic neuroligins are thought to perform essential functions in synapse validation and synaptic transmission by binding to, and dimerizing, presynaptic α- and β-neurexins. To test this hypothesis, we examined the functional effects of neuroligin-1 mutations that impair only α-neurexin binding, block both α- and β-neurexin binding, or abolish neur
Nature Publishing Group.
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3. Localized chemical release from an artificial synapse chip
A device that releases chemical compounds in small volumes and at multiple, well defined locations would be a powerful tool for clinical therapeutics and biological research. Many biomedical devices such as neurotransmitter-based prostheses or drug delivery devices require precise release of chemical compounds. Additionally, the ability to control chemical g
National Academy of Sciences.
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4. Postsynaptic activation at the squid giant synapse by photolytic release of L-glutamate from a 'caged' L-glutamate.
1. Pharmacological evidence suggests L-glutamate is a strong candidate as a transmitter at the giant synapse of the squid. Postsynaptic activation at the giant synapse cannot be effected by conventional application of putative neurotransmitters by iontophoresis or perfusion, apparently because the complex structure of the synapse prevents a sufficiently rapi
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5. Visualizing the Live Drosophila Glial-neuromuscular Junction with Fluorescent Dyes
Our project identified GFP labeled glial structures at the developing larval fly neuromuscular synapse. To look at development of live glial-nerve-muscle synapses, we developed a larval tissue preparation that had features of live intact larvae, but also had good optical properties. This new preparation also allowed for access of perfusates to the synapse.
MyJove Corporation.
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6. Calcium role in depolarization-secretion coupling: an aequorin study in squid giant synapse.
Aequorin, a protein that emits light in the presence of calcium, was injected in the presynaptic terminal of the squid giant synapse. This injection was preceded by intracellular tetraethylammonium administration, which prolonged the duration of the presynaptic action potential. After this procedure light emission was evoked by single presynaptic spikes capa
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7. The Yeast Mer2 Gene Is Required for Chromosome Synapsis and the Initiation of Meiotic Recombination
Mutation of the MER2 gene of Saccharomyces cerevisiae confers meiotic lethality. To gain insight into the function of the Mer2 protein, we have carried out a detailed characterization of the mer2 null mutant. Genetic analysis indicates that mer2 completely eliminates meiotic interchromosomal gene conversion and crossing over. In addition, mer2 abolishes intr
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8. Cytotoxic T lymphocytes form an antigen-independent ring junction
Immunological synapses are organized cell-cell junctions between T lymphocytes and APCs composed of an adhesion ring, the peripheral supramolecular activation cluster (pSMAC), and a central T cell receptor cluster, the central supramolecular activation cluster (cSMAC). In CD8+ cytotoxic T lymphocytes, the immunological synapse is thought to facilitate specif
American Society for Clinical Investigation.
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9. Predictions of Phase-Locking in Excitatory Hybrid Networks: Excitation Does Not Promote Phase-Locking in Pattern-Generating Networks as Reliably as Inhibition
Phase-locked activity is thought to underlie many high-level functions of the nervous system, the simplest of which are produced by central pattern generators (CPGs). It is not known whether we can define a theoretical framework that is sufficiently general to predict phase-locking in actual biological CPGs, nor is it known why the CPGs that have been charac
American Physiological Society.