A B-lymphocyte activation molecule related to the nerve growth factor receptor and induced by cytokines in carcinomas.

AUTOR(ES)

Stamenkovic, I

RESUMO

B cells and primary carcinomas express a surface molecule, Bp50 (CDw40), absent from other hematopoietic cells and from normal epithelium, and thought to play a regulatory role in B-cell maturation and epithelial neoplasia. In this work the sequence of a cDNA clone encoding Bp50 was analyzed by a newly derived transition matrix method. Among several interesting relationships with known receptors was found an extensive homology with the nerve growth factor receptor. The mRNA is induced by gamma-interferon in both B cells and epithelial neoplasms, suggesting a role for the molecule in the development of carcinomas at sites of chronic inflammation.

Documentos Relacionados

• Coordinated action of IgE and a B-cell-stimulatory factor on the CD23 receptor molecule up-regulates B-lymphocyte growth.
• B-cell-stimulatory factor 1 reverses Fc receptor-mediated inhibition of B-lymphocyte activation.
• In vivo polyclonal B-lymphocyte activation elicited by murine viruses.
• Monocyte suppression of Fusobacterium nucleatum-induced human polyclonal B-lymphocyte activation.
• Molecular requirements for B-lymphocyte activation by Escherichia coli lipopolysaccharide.