A bispecific antibody recognizing influenza A virus M2 protein redirects effector cells to inhibit virus replication in vitro.
AUTOR(ES)
Fernandez-Sesma, A
RESUMO
Bispecific antibodies can be used to redirect cytotoxic T cells to kill virus-infected cells, overriding the need for major histocompatibility complex restriction. We produced a bispecific antibody (3F12) which binds influenza virus M2 protein and the T-cell receptor and can redirect staphylococcal enterotoxin B-activated T cells to kill influenza virus-infected cells and inhibit virus replication in vitro.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=190421Documentos Relacionados
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