A Calcium-Dependent Mechanism for Synapse and Nerve Cell Membrane Modulation*

AUTOR(ES)

Hydén, Holger

RESUMO

A theory is presented according to which the neuronal membrane and synapses are influenced by membrane-bound S100 protein and a membrane-associated network of actin-like, 20-Å-diameter, coiled filaments and the competition by both proteins for Ca2+. The discussion is based on observations made with fluorescein- and peroxidase-conjugated antiserum against S100 protein on isolated nerve cells. A small part of the S100 protein is membrane-bound in a polar localization that develops postnatally. The competition for Ca2+ can influence the state of the network filaments which uncoil on binding Ca2+ and affect differently the conformational state of synapses and membrane depending on the S100 protein content.

Documentos Relacionados

• Calcium-Dependent Norepinephrine Release from Presynaptic Nerve Endings In Vitro
• A rice membrane calcium-dependent protein kinase is induced by gibberellin.
• Reversible, calcium-dependent membrane association of human leukocyte 5-lipoxygenase.
• Calcium-dependent oligonucleotide antagonists specific for L-selectin.
• Chromaffin cell scinderin, a novel calcium-dependent actin filament-severing protein.