A computer simulation study of motoneuron models with active dendrites in response to synaptic inputs. / Estudo por simulação computacional de modelos de motoneurônios com dendrito ativo em resposta a entradas sinápticas.

AUTOR(ES)

Leonardo Abdala Elias

DATA DE PUBLICAÇÃO

2010

RESUMO

Mathematical models of motoneurons have been developed as an aid to the understanding of phenomena involving the neuromuscular system, but most of these models have been based on the hypothesis of a passive dendritic tree. This holds for anesthetized animals but not necessarily during normal motor behavior of the intact animal. Experiments with decerebrate animals in which the monoaminergic tracts were maintained intact have shown that more complex behaviors may emerge in motoneurons due to dendritic voltage-gated ionic conductances, which are responsible for a persistent inward current. Therefore, the first aim of this work was to develop computationally-efficient new motoneuron models of different types (i.e. type S, FR and FF) that include a dendritic L-type calcium conductance so that bistability, plateau potential and enhancement of effective synaptic current may be generated. The second aim of this research was to evaluate the effects of the active dendritic ionic conductance on the input-output mapping of presynaptic to postsynaptic spike trains. The new models were parameterized based on data reported in experimental literature on the decerebrate cat preparation, and they were validated using appropriate protocols for either fully or partially bistable dynamics. The synaptic inputs were simulated by Poisson point processes and the output spike trains were analyzed. Sinusoidal modulation of the point process intensity was used for the estimation of each models frequency response. The results suggested that an active dendritic ionic conductance in motoneurons has a functional role during postural tasks, because, when activated, the persistent inward current enhances the motoneuronal excitability, reducing the variability of interspike intervals, and focusing the sensitivity of the models to low frequency inputs that correspond to the low-frequency oscillations that typically occur during quiet standing posture.

ASSUNTO(S)

compartmental models bistability plateau potential integração sináptica canal de cálcio do tipo l persistent currents l-type calcium channel correntes persistentes modelos comportamentais biestabilidade

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