A consistency-based consensus algorithm for de novo and reference-guided sequence assembly of short reads

AUTOR(ES)

Rausch, Tobias

FONTE

Oxford University Press

RESUMO

Motivation: Novel high-throughput sequencing technologies pose new algorithmic challenges in handling massive amounts of short-read, high-coverage data. A robust and versatile consensus tool is of particular interest for such data since a sound multi-read alignment is a prerequisite for variation analyses, accurate genome assemblies and insert sequencing.

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