A feedback mechanism regulates monoallelic odorant receptor expression
AUTOR(ES)
Lewcock, Joseph W.
FONTE
National Academy of Sciences
RESUMO
In olfactory neurons, expression of a single odorant receptor (OR) from a repertoire of >1,000 genes is required for odor coding and axonal targeting. Here, we demonstrate a role for OR protein as an essential regulator in the establishment of monoallelic OR expression. An OR-promoter-driven reporter expresses in a receptor-like pattern but, unlike a native OR, is coexpressed with an additional OR allele. Expression of a functional OR from the identical promoter eliminates expression of other OR alleles. The presence of an untranslatable OR coding sequence in the mRNA is insufficient to exclude expression of a second OR. Together, these data identify the OR protein as a critical element in a feedback pathway that regulates OR selection.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=327152Documentos Relacionados
- Olfaction: Transient expression of a putative odorant receptor in the avian notochord
- Functional expression and characterization of a Drosophila odorant receptor in a heterologous cell system
- ODORANT1 Regulates Fragrance Biosynthesis in Petunia FlowersW⃞
- PTEN Expression Causes Feedback Upregulation of Insulin Receptor Substrate 2
- The spatial distributions of odorant sensitivity and odorant-induced currents in salamander olfactory receptor cells.
