A gamma-aminobutyric-acid-mediated inhibition of neurones in the nucleus tractus solitarius of the cat.

AUTOR(ES)

Bennett, J A

RESUMO

1. Extracellular recordings were made from 123 synaptically activated neurones in the nucleus tractus solitarius of the chloralose-anaesthetized cat. 2. Ninety-one neurones were activated by electrical stimulation of cardiac or pulmonary vagal branches and thirty-two by stimulation of the aortic nerve. 3. Ionophoretic application of GABA abolished or markedly reduced the evoked or spontaneous activity of each neurone tested. These inhibitory effects were antagonized by the simultaneous ionophoretic application of bicuculline. 4. Glycine inhibited the evoked activity of 60% of neurones tested. This inhibition could be antagonized by the simultaneous application of strychnine. 5. Application of bicuculline alone increased the evoked or spontaneous activity of a large proportion of the neurones; strychnine alone had no significant effect on the evoked or spontaneous activity of the neurones. 6. These results are consistent with the hypothesis that GABA acts as an inhibitory transmitter substance within the nucleus tractus solitarius.

Documentos Relacionados

• A gamma-aminobutyric-acid-mediated baroreceptor input to supraoptic vasopressin neurones in the rat.
• Hypothalamic inhibition of neurones in the nucleus tractus solitarius of the cat is GABA mediated.
• Monosynaptic excitation of thoracic motoneurones by inspiratory neurones of the nucleus tractus solitarius in the cat.
• The role of gamma-aminobutyric acid mediated inhibition in the response properties of cat lateral geniculate nucleus neurones.
• Development of gamma-aminobutyric acid mediated inhibition of X cells of the cat lateral geniculate nucleus.