A Genetic Analysis of Deltex and Its Interaction with the Notch Locus in Drosophila Melanogaster
AUTOR(ES)
Gorman, M. J.
RESUMO
During Drosophila development networks of genes control the developmental pathways that specify cell fates. The Notch gene is a well characterized member of some cell fate pathways, and several other genes belonging to these same pathways have been identified because they share a neurogenic null phenotype with Notch. However, it is unlikely that the neurogenic genes represent all of the genes in these pathways. The goal of this research was to use a genetic approach to identify and characterize one of the other genes that acts with Notch to specify cell fate. Mutant alleles of genes in the same pathway should have phenotypes similar to Notch alleles and should show phenotypic interactions with Notch alleles. With this approach we identified the deltex gene as a potential cell fate gene. An extensive phenotypic characterization of loss-of-function deltex phenotypes showed abnormalities (such as thick wing veins, double bristles and extra cone cells) that suggest that deltex is involved in cell fate decision processes. Phenotypic interactions between deltex and Notch as seen in double mutants showed that Notch and deltex do not code for duplicate functions and that the two genes function together in many different developing tissues. The results of these investigations lead to the conclusion that the deltex gene functions with the Notch gene in one or more developmental pathways to specify cell fate.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1204970Documentos Relacionados
- Deltex, a Locus Interacting with the Neurogenic Genes, Notch, Delta and Mastermind in Drosophila Melanogaster
- A Genetic Analysis of the Stoned Locus and Its Interaction with Dunce, Shibire and Suppressor of Stoned Variants of Drosophila Melanogaster
- Interactions of Vestigial and Scabrous with the Notch Locus of Drosophila Melanogaster
- Genetic Analysis of the Hairy Locus in DROSOPHILA MELANOGASTER
- Genetic Analysis of the Enhancer of Zeste Locus and Its Role in Gene Regulation in Drosophila Melanogaster