A Genetic Locus for Inducibility of C-Type Virus in BALB/c Cells: The Effect of a Nonlinked Regulatory Gene on Detection of Virus after Chemical Activation
AUTOR(ES)
Stephenson, John R.
RESUMO
Previous studies have shown that chemicals can transiently activate endogenous C-type viruses from embryo cells of the BALB/c mouse strain, but not from cells of another mouse strain, NIH Swiss. The number of genetic loci for inducibility of endogenous virus in BALB/c cells was investigated with cell lines derived from appropriate, F1, F2-hybrid, and backcross generation embryos of these strains. A single genetic locus responsible for inducibility of virus in BALB/c cells was detected, and tentatively designated Ind. A second locus, previously described in studies of mouse-cell susceptibility to exogenous virus infection, Fv-1, was found to be genetically nonlinked to Ind. This regulatory gene plays an important role in determining whether the induced viruses of BALB/c cells can persist after chemical activation.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=389647Documentos Relacionados
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