A global representation of the protein fold space
AUTOR(ES)
Hou, Jingtong
FONTE
The National Academy of Sciences
RESUMO
One of the principal goals of the structural genomics initiative is to identify the total repertoire of protein folds and obtain a global view of the “protein structure universe.” Here, we present a 3D map of the protein fold space in which structurally related folds are represented by spatially adjacent points. Such a representation reveals a high-level organization of the fold space that is intuitively interpretable. The shape of the fold space and the overall distribution of the folds are defined by three dominant trends: secondary structure class, chain topology, and protein domain size. Random coil-like structures of small proteins and peptides are mapped to a region where the three trends converge, offering an interesting perspective on both the demography of fold space and the evolution of protein structures.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=151350Documentos Relacionados
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