A growth arrest-specific (gas) gene codes for a membrane protein.
AUTOR(ES)
Manfioletti, G
RESUMO
A set of growth arrest-specific (gas) genes whose expression is negatively regulated by serum has recently been identified. We report on the detailed analysis of one of these genes (gas3). The kinetics of regulation by the presence and absence of serum were investigated, and it was found that this gene is regulated at the post-transcriptional level. The encoded protein deduced from the nucleotide sequence showed some similarity to a mitochondrial oxyreductase, and in vitro translation established that the protein product is a transmembrane glycoprotein.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=360655Documentos Relacionados
- Regulation and expression of a growth arrest-specific gene (gas5) during growth, differentiation, and development.
- A myelin protein is encoded by the homologue of a growth arrest-specific gene.
- Hematopoietic progenitor cells grow on 3T3 fibroblast monolayers that overexpress growth arrest-specific gene-6 (GAS6)
- Regulation of expression of growth arrest-specific genes in mouse fibroblasts.
- Cloning of a growth arrest-specific and transforming growth factor beta-regulated gene, TI 1, from an epithelial cell line.