A Highly Attenuated Measles Virus Vaccine Strain Encodes a Fully Functional C Protein▿

AUTOR(ES)

Nakatsu, Yuichiro

FONTE

American Society for Microbiology (ASM)

RESUMO

The P, V, and C proteins of measles virus are encoded in overlapping reading frames of the P gene, which makes it difficult to analyze the functions of the individual proteins in the context of virus infection. We established a system to analyze the C protein independently from the P and V proteins by placing its gene in an additional transcription unit between the H and L genes. Analyses with this system indicated that a highly attenuated Edmonston lineage vaccine strain encodes a fully functional C protein, and the P and/or V protein is involved in the attenuated phenotype.

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