A histidine protein kinase homologue required for regulation of bacterial cell division and differentiation.
AUTOR(ES)
Ohta, N
RESUMO
Differentiation in the dimorphic bacterium Caulobacter crescentus results from a sequence of discontinuous, stage-specific events that leads to the production of a stalked cell and a new motile swarmer cell after each asymmetric cell division. As reported previously, pseudoreversion analysis of mutations in the pleiotropic developmental gene pleC identified three cell division genes: divJ, divK, and divL. We show here that one of these genes, divJ, encodes a predicted protein of 596 residues with an extensive hydrophobic N-terminal region and a C-terminal domain containing all of the invariant residues found in the family of bacterial histidine protein kinases. Our results also show that divJ is discontinuously transcribed early in the swarmer cell cycle during a period that coincides with the G1 to S transition. We propose that the DivJ protein is one member of a signal transduction pathway regulating the cell cycle and differentiation in Caulobacter and that protein modification by phosphorylation may play a central role in coupling developmental events to progress through the cell division cycle.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=50325Documentos Relacionados
- A novel bacterial tyrosine kinase essential for cell division and differentiation
- The Significance of Microspore Division and Division Symmetry for Vegetative Cell-Specific Transcription and Generative Cell Differentiation.
- Protein kinase C activity and hexamethylenebisacetamide-induced erythroleukemia cell differentiation.
- Regulation of embryonic cell division by a Xenopus gastrula-specific protein kinase.
- Mitogen-activated protein kinase activation is insufficient for growth factor receptor-mediated PC12 cell differentiation.