A histone H1 protein in sea urchins is encoded by a poly(A)+ mRNA.
AUTOR(ES)
Lieber, T
RESUMO
Typical histone genes lack intervening sequences and encode small mRNAs (400-800 nucleotides) with short leader and trailer regions. Most histone mRNAs are not polyadenylylated but rather terminate in a highly conserved stem and loop structure. The early, late, and testis-specific histone genes of sea urchins, described to date, have this typical histone gene structure. We have identified an unusual H1 gene, H1-delta, in sea urchins that encodes a poly(A)+ mRNA. This mRNA is one of a group of polyadenylylated transcripts homologous with H1 gene probes. The sequence of H1-delta had been determined. H1-delta encodes a different H1 protein. Although the temporal expression of H1-delta mRNA is similar to that of other late H1 (beta and gamma) mRNAs, its spatial distribution at the time of maximal accumulation is distinct and confirms that H1-delta is regulated differently than other H1 genes.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=280378Documentos Relacionados
- Olfactory neuron-specific protein is translated from a large poly(A)+ mRNA.
- A genomic clone encoding a novel proliferation-dependent histone H2A.1 mRNA enriched in the poly(A)+ fraction.
- Cell cycle regulation of human histone H1 mRNA.
- Light-regulated protein and poly(A)+ mRNA synthesis in Neurospora crassa.
- GRSF-1: a poly(A)+ mRNA binding protein which interacts with a conserved G-rich element.
