A importancia do complexo de sinalização associado a quinase de adesão focal (FAK) em corações de camundongos MDX submetidos a sobrecarga pressora
AUTOR(ES)
Thais Holtz Theizen
DATA DE PUBLICAÇÃO
2004
RESUMO
Mechanisms involved in the transduction of mechanical stimuli into biochemical signals in the myocardium are not fully understood. Experimental evidences suggested an important role of the sarcomeric cytoskeleton and extra-sarcomeric in transduction of mechanical stimuli into biochemical signals in the cardiomyocytes. Presumably, these structures participate in the mechano-biochemical signal transduction through proteins located in the cytoskeleton responsive to tension, induced by mechanical stimuli. Recent data have been suggested that Focal adhesion molecule (Fak) could be a molecule involved in the transduction of the mechanical stimuli. The aim of the present study is to investigate the activation and expression of Fak in the myocardium of dystrophin-deficient mdx mice (MDX). Westem blot studies demonstrated an increase in the Fak basal phosphorilation (approximately 3 times) in the MDX mice submitted to transversal aortic constriction (TAC), when compared to swiss mice not submitted to TAC...Note: The complete abstract is available with the full electronic digital thesis or dissertations
ASSUNTO(S)
ACESSO AO ARTIGO
http://libdigi.unicamp.br/document/?code=vtls000374348Documentos Relacionados
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