A MecA Paralog, YpbH, Binds ClpC, Affecting both Competence and Sporulation
AUTOR(ES)
Persuh, Marjan
FONTE
American Society for Microbiology
RESUMO
ComK, the master regulator of competence, is degraded by the general stress-related protease ClpCP but must be targeted to this protease by binding to the adapter protein MecA. The genome of Bacillus subtilis contains a paralog of mecA, ypbH. We show in the present study that YpbH, like MecA, binds ClpC and that its elimination or overproduction affects competence and sporulation.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=134970Documentos Relacionados
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