A model of the detection of warmth and cold by cutaneous sensors through effects on voltage-gated membrane channels
AUTOR(ES)
Adair, Robert K.
FONTE
The National Academy of Sciences
RESUMO
Warmth and cold sensations are known to derive from separate warm and cold cutaneous thermoreceptors in the form of differentiated afferent nerves. The firing rate of warm-sensing nerves increases as the temperature increases; the firing rate of cold-sensing nerves increases if the temperature is reduced. I postulate that the primary sensitivity of the warm sensors derives from voltage-gated Ca2+ membrane channels configured such that an increase in temperature opens channels and increases the ion influx while a reduction in temperature increases the ion influx through voltage-gated Na+ channels in the cold sensory nerve ends. In either case, the initial cation influx causes a small cellular depolarization that further opens Ca2+ channels, admitting more cations in a positive feedback process that leads to the depolarization of the membrane, thus initiating an action potential pulse. Monte Carlo calculations based on a well defined model of such processes, which include effects of noise, demonstrate quantitative agreement of the model with an extensive body of data.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=18371Documentos Relacionados
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